Recombinant Human Thyroid Stimulating Hormone Beta

• Cat.No.: TSHB-51H
• Product Overview: Recombinant Human Thyroid Stimulating Hormone Beta was expressed in yeast.

Specification

• Description: Thyrotropin-stimulating hormone (TSH) is a noncovalently linked glycoprotein heterodimer and is part of a family of pituitary hormones containing a common alpha subunit (TSHA) and a unique beta subunit that confers specificity.Using bovine TSHB cDNA as probe, Hayashizaki et al. (1985) cloned TSHB from human liver and leukocyte genomic DNA libraries. Human TSHB encodes a deduced protein consisting of a 20-amino acid signal sequence, a mature protein of 112 amino acids, and a C-terminal extension of 6 hydrophobic amino acids. Wondisford et al. (1988) also cloned the human TSHB gene.Wondisford et al. (1988) determined that the TSHB gene contains 3 exons, the first of which is noncoding. The rat TSHB gene also contains one 5-prime noncoding exon, whereas the mouse Tshb gene contains 3.
• Source: Yeast
• Species: Human
• Form: Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >95 % as determined by SDS-PAGE
• Applications: Western blotting, ELISA
• Storage: Store it under sterile conditions at -20℃ to -101℃ upon receiving.Recommend to aliquot the protein into smaller quantities for optimal storage.

Gene Information

• Gene Name: TSHB thyroid stimulating hormone, beta [ Homo sapiens ]
• Official Symbol: TSHB
• Synonyms: TSHB; thyroid stimulating hormone, beta; thyrotropin subunit beta; thyrotropin beta chain; thyrotropin beta subunit; thyroid-stimulating hormone subunit beta; TSH-B; TSH-BETA
• Gene ID: 7252
• mRNA Refseq: NM_000549
• Protein Refseq: NP_000540
• MIM: 188540
• UniProt ID: P01222
• Chromosome Location: 1p13
• Pathway: Amine-derived hormones, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem
• Function: hormone activity