Recombinant Human CD5 protein, His-tagged
Cat.No. : | CD5-175H |
Product Overview : | Recombinant Human CD5 (Arg25-Pro372) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
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- Gene Information
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Description : | T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Arg25 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 40.5 kDa. The protein migrates as 48-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Arg25-Pro372 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | CD5 |
Official Symbol : | CD5 |
Synonyms : | CD5; CD5 molecule; CD5 antigen (p56 62) , LEU1; T-cell surface glycoprotein CD5; T1; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; LEU1 |
Gene ID : | 921 |
mRNA Refseq : | NM_014207 |
Protein Refseq : | NP_055022 |
MIM : | 153340 |
UniProt ID : | P06127 |
Products Types
◆ Recombinant Protein | ||
Cd5-843M | Recombinant Mouse Cd5 Protein, MYC/DDK-tagged | +Inquiry |
CD5-1093H | Recombinant Human CD5 Protein (Met1-Pro372), HlgG1 Fc-tagged | +Inquiry |
CD5-915R | Recombinant Rat CD5 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD5-163H | Recombinant Human CD5 Protein, His-tagged | +Inquiry |
CD5-0830H | Recombinant Human CD5 Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CD5-1293RCL | Recombinant Rat CD5 cell lysate | +Inquiry |
CD5-2498MCL | Recombinant Mouse CD5 cell lysate | +Inquiry |
CD5-2572HCL | Recombinant Human CD5 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere are interactions between CD5 and other biomolecules. For example, it binds to antigens and antibodies and participates in the activation and differentiation of immune cells, and also binds to other signal transduction molecules and participates in cell signal transduction.
Certain biomolecules can be used as molecular markers of CD5, including CD5 antigens detected on the surface of lymphocytes, as well as related proteins and genes that interact with CD5. These markers can be used for early diagnosis of diseases, prognosis judgment, or monitoring the effectiveness of treatment.
Assessing the efficacy and safety of treatments targeting CD5 requires clinical trials and drug monitoring. The effectiveness of the treatment was evaluated by designing a rigorous clinical trial protocol that compared the disease remission rate, symptom improvement, and quality of life improvement between the treatment and control groups. At the same time, drug monitoring is used to monitor the safety and efficacy of drugs in actual use, adjust treatment regimens in a timely manner, maximize the efficacy of drugs and reduce the risk of side effects.
CD5 has a typical immunoglobulin superfamily domain, which is a single-stranded transmembrane glycoprotein that is distributed in an asymmetrical manner across the cell membrane. This structure allows it to bind to antigens and antibodies and participate in the immune response.
CD5 has been linked to a number of immune system-related diseases. For example, certain autoimmune diseases, allergic reactions, transplant rejection, etc. In addition, CD5 has been implicated in the development and progression of certain tumors.
Treatment strategies for CD5 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of antibody drugs or small molecule inhibitors against CD5 to inhibit its overactivation in the immune response, or the regulation of CD5 expression through gene knockout or overexpression techniques.
Customer Reviews (3)
Write a reviewThe stability of CD5 is very good, and even if it is stored for a long time, it will not affect its performance.
I have recommended it to other students, the price is affordable, the operation is convenient, and the effect is good.
I'm very happy with the results, the stability is strong.
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