Recombinant Human IL21, His-tagged
Cat.No. : | IL21-15H |
Product Overview : | Recombinant Human Interleukin-21/IL-21 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln23-Ser155) of Human IL-21 fused with a polyhistidine tag at the C-terminus. |
- Specification
- Gene Information
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Description : | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Source : | Human cells |
Species : | Human |
Tag : | His |
AA Sequence : | QGQDRHMIRMRQLIDIVDQLKNYVN DLVPEFLPAPEDVETNCEWSAFSCF QKAQLKSANTGNNER IINVSIKKLKRKPPSTNAGRRQKHR LTCPSCDSYEKKPPKEFLERFKSLL QKMIHQHLSSRTHGS EDSVDHHHHHH |
Endotoxin : | Less than 0.1 ng/µg (1 IEU/µg). |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Gene Name : | IL21 interleukin 21 [ Homo sapiens (human) ] |
Official Symbol : | IL21 |
Synonyms : | IL21; interleukin 21; Za11; IL-21; CVID11; interleukin-21; interleukin-21 isoform |
Gene ID : | 59067 |
mRNA Refseq : | NM_021803 |
Protein Refseq : | NP_068575 |
MIM : | 605384 |
UniProt ID : | Q9HBE4 |
Chromosome Location : | 4q26-q27 |
Pathway : | Cytokine-cytokine receptor interaction; Inflammatory bowel disease (IBD); Jak-STAT signaling pathway |
Function : | cytokine activity; cytokine receptor binding; interleukin-2 receptor binding |
Products Types
◆ Recombinant Protein | ||
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IL21-4336R | Recombinant Rabbit IL21 Protein | +Inquiry |
IL21-362I | Active Recombinant Human IL21 Protein (132 aa) | +Inquiry |
◆ Lysates | ||
IL21-001RCL | Recombinant Rat IL21 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionIL21 has demonstrated efficacy in preclinical and clinical studies for various cancers, including melanoma, renal cell carcinoma, and lymphoma.
Common side effects may include fatigue, fever, and flu-like symptoms. However, the severity and type of side effects can vary among individuals.
IL21 is often investigated in combination with other cancer therapies to enhance its effectiveness, and it has shown promise in combination treatments.
Yes, several clinical trials are investigating the efficacy and safety of IL21 in autoimmune diseases, such as rheumatoid arthritis and lupus.
IL21 promotes the differentiation and survival of memory T cells, contributing to the long-term immune response against pathogens.
Customer Reviews (3)
Write a reviewWith the IL21 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.
I am confident that incorporating the IL21 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes
Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.
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