Active Recombinant Human KITLG, His tagged
Cat.No. : | KITLG-521H |
Product Overview : | Recombinant Human Stem Cell Factor/SCF is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Glu26-His214) of Human KITLG fused with a polyhistidine tag at the C-terminus. |
- Specification
- Gene Information
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Description : | Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. |
Source : | Human Cells |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2 μM filtered solution of PBS,pH 7.4. |
Bio-activity : | >2.0 x 10^5 U/mg |
Endotoxin : | Less than 0.1 EU/μg. |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at< -20°c, though stable at room temperature for 3>Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at< -20°c for 5> |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 3X PBS.Please aliquot the reconstituted solution. |
Gene Name : | KITLG KIT ligand [ Homo sapiens ] |
Official Symbol : | KITLG |
Synonyms : | KITLG; KIT ligand; MGF; kit ligand; familial progressive hyperpigmentation 2; FPH2; Kitl; KL 1; mast cell growth factor; SCF; SF; steel factor; stem cell factor; c-Kit ligand; KL-1; SHEP7; kit-ligand; DKFZp686F2250; |
Gene ID : | 4254 |
mRNA Refseq : | NM_000899 |
Protein Refseq : | NP_000890 |
MIM : | 184745 |
UniProt ID : | P21583 |
Chromosome Location : | 12q22 |
Pathway : | C-MYB transcription factor network, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Kit Receptor Signaling Pathway, organism-specific biosystem; Melanogenesis, organism-specific biosystem; |
Function : | cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding; |
Products Types
◆ Recombinant Protein | ||
KITLG-199H | Active Recombinant Human KITLG Protein | +Inquiry |
KITLG-217H | Active Recombinant Human KITLG Protein (Glu26-Ala189), C-His tagged, Animal-free, Carrier-free | +Inquiry |
KITLG-325H | Active Recombinant Human KITLG Protein, His & Avi-tagged, Biotinylated | +Inquiry |
Kitl-552M | Recombinant Mouse Kitl Protein | +Inquiry |
KITLG-4356R | Recombinant Rabbit KITLG Protein | +Inquiry |
◆ Lysates | ||
KITLG-583MCL | Recombinant Mouse KITLG cell lysate | +Inquiry |
KITLG-571HCL | Recombinant Human KITLG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionOverexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.
Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.
KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.
Customer Reviews (3)
Write a reviewReliable for immunoprecipitation assay.
No contamination, very clean.
Worked perfectly in Western.
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