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Active Recombinant Human BRD2, His&FLAG-tagged

Cat.No. : BRD2-35H
Product Overview : Recombinant Human BRD2 corresponding to amino acids 71-194 that contains the bromodomain sequences of BRD2 (accession number NP_005095.1) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag.
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  • Gene Information
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Description : Bromodomain-containing protein 2 (BRD2), also known as RING3, belongs to the BET subclass of proteins, which are characterized by two N-terminal bromodomains and one ET (Extra Terminal) domain. BRDs associate with chromatin through their bromodomains that recognize acetylated histone lysine residues. Bromodomains function as "readers" of these epigenetic histone marks and regulate chromatin structure and gene expression by linking associated proteins to the acetylated nucleosomal targets. The ET domain functions as a protein binding motif and exerts atypical serine-kinase activity. The BET family consists of at least four members in mouse and human, BRD2 (also referred to as FSRG1, RING3), BRD3 (FSRG2, ORFX), BRD4 (FSRG4, MCAP/HUNK1), and BRDT (FSRG3, BRD6). BRD proteins are related to the female Sterile Homeotic protein in Drosophila, a gene required maternally for proper expression of other homeotic genes, such as Ubx, which is involved in pattern formation. BRD2 causes elevated protein kinase activity in leukemias. Transgenic mice overexpressing BRD2 in the lymphoid system develop diffuse large-cell lymphoma. BRD2 has been shown to interact with E2F1 and with histone H4 acetylated at Lys12 via its two bromodomains. BRD2 may play a role in spermatogenesis or folliculogenesis. Genetic evidence links the BRD2 gene to both juvenile myoclonic epilepsy and photoparoxysomal responses.
Source : E. coli
Species : Human
Tag : His&FLAG
Form : 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol.
Bio-activity : Binding specificity for acetylated H4K5, H4K5/8, H4K5/12, H4K8/12, H4K12/16, H4K12/16/20 and H4K5/8/12/16.
Molecular Mass : 20.78 kDa
Applications : Binding assays, inhibitor screening, and selectivity profiling.
Storage : Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Concentration : 5.3 mg/ml
Gene Name : BRD2 bromodomain containing 2 [ Homo sapiens ]
Official Symbol : BRD2
Synonyms : BRD2; bromodomain containing 2; bromodomain-containing protein 2; D6S113E; FSRG1; KIAA9001; NAT; RING3; O27.1.1; bromodomain-containing 2; really interesting new gene 3 protein; female sterile homeotic-related gene 1; FSH; RNF3; FLJ31942; DKFZp686N0336;
Gene ID : 6046
mRNA Refseq : NM_001113182
Protein Refseq : NP_001106653
MIM : 601540
UniProt ID : P25440
Chromosome Location : 6p21.3
Pathway : Regulation of retinoblastoma protein, organism-specific biosystem;
Function : protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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