Active Recombinant Human SETDB1, FLAG-tagged
Cat.No. : | SETDB1-70H |
Product Overview : | Recombinant Human SETDB1 (accession number NP_001138887.1) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 145 kDa. |
- Specification
- Gene Information
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Description : | SETDB1 (SET Domain, Bifurcated 1) is a histone methyltransferase that methylates histone H3 at lysine 9. H3K9 methylation is associated with transcriptional repression and gene silencing through recruitment of HP1 proteins to methylated histones. H3K9 trimethylation is coordinated with DNA methylation, most likely through formation of a complex with MBD1 and ATF7IP that leads to transcriptional repression. SETDB1 activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28, a factor recruited by KRAB zinc-finger proteins. Aberrant SETDB1 function is associated with the pathogenesis of Huntington Disease. |
Source : | Sf9 insect cells |
Species : | Human |
Tag : | FLAG |
Form : | 25 mM HEPES, pH 7.5, 150 mM NaCl and 5% glycerol. |
Bio-activity : | H3K9me3 methyltransferase. |
Applications : | Enzyme kinetics, inhibitor screening, and selectivity profiling. |
Storage : | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
Concentration : | 1 mg/ml |
Gene Name : | SETDB1 SET domain, bifurcated 1 [ Homo sapiens ] |
Official Symbol : | SETDB1 |
Synonyms : | SETDB1; SET domain, bifurcated 1; histone-lysine N-methyltransferase SETDB1; ESET; KG1T; KIAA0067; KMT1E; H3-K9-HMTase 4; lysine N-methyltransferase 1E; histone H3-K9 methyltransferase 4; ERG-associated protein with SET domain; ERG-associated protein with a SET domain, ESET; histone-lysine N-methyltransferase, H3lysine-9 specific 4; H3-K9-HMTase4; |
Gene ID : | 9869 |
mRNA Refseq : | NM_001145415 |
Protein Refseq : | NP_001138887 |
MIM : | 604396 |
UniProt ID : | Q15047 |
Chromosome Location : | 1q21 |
Pathway : | Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Noncanonical Wnt signaling pathway, organism-specific biosystem; |
Function : | DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
SETDB1-2120H | Recombinant Human SETDB1 Protein (1-397 aa), GST-tagged | +Inquiry |
SETDB1-1986H | Recombinant Human SETDB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SETDB1-12H | Recombinant Human SETDB1 Protein (510-1290, end), N His-FLAG tagged | +Inquiry |
Setdb1-5802M | Recombinant Mouse Setdb1 Protein, Myc/DDK-tagged | +Inquiry |
SETDB1-3204H | Recombinant Human SETDB1 protein, His-tagged | +Inquiry |
◆ Lysates | ||
SETDB1-1923HCL | Recombinant Human SETDB1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1865 | SetDB1 Chemiluminescent Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (6)
Ask a questionThe current treatments for SETDB1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for chromatin modification.
If the level of SETDB1 recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.
SETDB1 recombinant protein is associated with some tumors, neurological diseases, and autoimmune diseases.
The level of SETDB1 recombinant protein can be detected by gene sequencing and protein detection methods.
The level of SETDB1 recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.
Some studies have shown that SETDB1 recombinant protein may be involved in the development and progression of tumors, especially in neurological tumors and lymphomas.
Customer Reviews (3)
Write a reviewSETDB1 has shown good biocompatibility and safety in related experiments.
SETDB1 has good solubility and is easy to handle and purify.
SETDB1 is consistent and reliable, with no significant differences between batches.
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