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Active Recombinant Human SETDB1, FLAG-tagged

Cat.No. : SETDB1-70H
Product Overview : Recombinant Human SETDB1 (accession number NP_001138887.1) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 145 kDa.
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Description : SETDB1 (SET Domain, Bifurcated 1) is a histone methyltransferase that methylates histone H3 at lysine 9. H3K9 methylation is associated with transcriptional repression and gene silencing through recruitment of HP1 proteins to methylated histones. H3K9 trimethylation is coordinated with DNA methylation, most likely through formation of a complex with MBD1 and ATF7IP that leads to transcriptional repression. SETDB1 activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28, a factor recruited by KRAB zinc-finger proteins. Aberrant SETDB1 function is associated with the pathogenesis of Huntington Disease.
Source : Sf9 insect cells
Species : Human
Tag : FLAG
Form : 25 mM HEPES, pH 7.5, 150 mM NaCl and 5% glycerol.
Bio-activity : H3K9me3 methyltransferase.
Applications : Enzyme kinetics, inhibitor screening, and selectivity profiling.
Storage : Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Concentration : 1 mg/ml
Gene Name : SETDB1 SET domain, bifurcated 1 [ Homo sapiens ]
Official Symbol : SETDB1
Synonyms : SETDB1; SET domain, bifurcated 1; histone-lysine N-methyltransferase SETDB1; ESET; KG1T; KIAA0067; KMT1E; H3-K9-HMTase 4; lysine N-methyltransferase 1E; histone H3-K9 methyltransferase 4; ERG-associated protein with SET domain; ERG-associated protein with a SET domain, ESET; histone-lysine N-methyltransferase, H3lysine-9 specific 4; H3-K9-HMTase4;
Gene ID : 9869
mRNA Refseq : NM_001145415
Protein Refseq : NP_001138887
MIM : 604396
UniProt ID : Q15047
Chromosome Location : 1q21
Pathway : Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Noncanonical Wnt signaling pathway, organism-specific biosystem;
Function : DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the treatments for SETDB1 recombinant protein? 11/24/2022

The current treatments for SETDB1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for chromatin modification.

If the level of SETDB1 recombinant protein is abnormal, what should I do? 10/27/2022

If the level of SETDB1 recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

What diseases is SETDB1 recombinant protein associated with? 12/16/2021

SETDB1 recombinant protein is associated with some tumors, neurological diseases, and autoimmune diseases.

How can I detect the level of SETDB1 recombinant protein? 12/27/2020

The level of SETDB1 recombinant protein can be detected by gene sequencing and protein detection methods.

Does SETDB1 work in pregnant women? 10/03/2020

The level of SETDB1 recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.

What is the association between SETDB1 recombinant protein and tumors? 04/14/2020

Some studies have shown that SETDB1 recombinant protein may be involved in the development and progression of tumors, especially in neurological tumors and lymphomas.

Customer Reviews (3)

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Reviews
04/12/2023

    SETDB1 has shown good biocompatibility and safety in related experiments.

    01/04/2023

      SETDB1 has good solubility and is easy to handle and purify.

      03/29/2022

        SETDB1 is consistent and reliable, with no significant differences between batches.

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