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GMP Recombinant Human BMP2

Cat.No. : BMP2-123H
Product Overview : GMP Recombinant Human Bone Morphogenetic Protein 2/BMP2 is produced by our E. coli expression system. The target protein is expressed with sequence (Gln283-­-Arg396) of Human BMP2.
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Description : Bone Morphogenetic Proteins (BMPs) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2 μM filtered solution of 50mM HAc.
Bio-activity : ED50 is less than 50 ng/ml. Specific Activity of 2.0x104 IU/mg, measured by the cytolysis of MC3T3-E1 cells.
AA Sequence : MQAKHKQRKRLKSSCKRHPLYVDFS DVGWNDWIVAPPGYHAFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Endotoxin : Less than 0.1 ng/µg (0.1 IEU/µg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Storage : Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping : The product is shipped at ambient temperature.
Publication :
Protein engineering of recombinant human bone morphogenetic protein 2 with higher interaction with Ca phosphate based scaffold used for osteogenesis (2017)
Gene Name : BMP2 bone morphogenetic protein 2 [ Homo sapiens ]
Official Symbol : BMP2
Synonyms : BMP2; bone morphogenetic protein 2; BMP2A; BMP-2A; bone morphogenetic protein 2A; BDA2;
Gene ID : 650
mRNA Refseq : NM_001200
Protein Refseq : NP_001191
MIM : 112261
UniProt ID : P12643
Chromosome Location : 20p12
Pathway : Adipogenesis, organism-specific biosystem; BMP Signalling Pathway, organism-specific biosystem; Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Heart Development, organism-specific biosystem;
Function : BMP receptor binding; SMAD binding; activin receptor activity, type II; cytokine activity; growth factor activity; phosphatase activator activity; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; receptor binding; retinol dehydrogenase activity; transmembrane receptor protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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05/06/2023

    We have tested the recombinant protein in our ELISAs and it performs well.

    02/01/2023

      I'm pleased with your recombinant products. It is done well in our experiment.

      01/29/2023

        Very nice puchase experience with all of you.

        08/06/2022

          I’ve used the products you provided, and they all work good in my study.

          04/09/2021

            Thanks so much! Your protein performed really well,

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