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Human C1-Inhibitor Reference standard

Cat.No. : SERPING1-27H
Product Overview : The intended use of this preparation is to calibrate the measurement of functional C1-inhibitor in products derived from human plasma used in replacement therapy. The reference standard has not been evaluated for the potency estimation of recombinant products.
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Species : Human
Enzyme Unit : The assigned potency of this preparation is: 9.6 IU/ ampoule
Usage : No attempt should be made to weigh out any portion of the freeze-dried material prior to reconstitution Allow the ampoule to reach ambient temperature before opening and reconstitute with 1.0 ml distilled water.
Notes : This preparation is not for administration to humans. The preparation contains material of human origin, and either the final product or the source materials, from which it is derived, have been tested and found negative for HBsAg, anti-HIV and HCV RNA. As with all materials of biological origin, this preparation should be regarded as potentially hazardous to health. It should be used and discarded according to your own laboratorys safety procedures. Such safety procedures should include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening ampoules or vials, to avoid cuts.
Stability : Reference materials are held at Creative Biomart within assured, temperature- controlled storage facilities. Reference Materials should be stored on receipt as indicated on the label. They remain valid with the assigned potency and status until withdrawn or amended. To provide predictions on the long term stability of the reference standard the C1-inhibitor potency of ampoules stored under accelerated degradation conditions is being monitored over time. After one year little or no potency loss was observed for samples stored up to +56°C. Based on the results of a stability test, it is advised that samples are stored on wet ice following reconstitution, and potency assays should be completed within 4 hours of reconstitution.
Storage : Upon receipt unopened ampoules should be stored in the dark at or below -20°C. Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature.
Gene Name : SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 [ Homo sapiens ];
Official Symbol : SERPING1
Synonyms : SERPING1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; C1NH, serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary); plasma protease C1 inhibitor; angioedema; hereditary; C1 INH; C1IN; HAE1; HAE2; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1; C1NH; C1INH;
Gene ID : 710
mRNA Refseq : NM_000062
Protein Refseq : NP_000053
MIM : 606860
UniProt ID : P05155
Chromosome Location : 11q12-q13.1
Pathway : Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem; Intrinsic Pathway, organism-specific biosystem; Pertussis, organism-specific biosystem;
Function : complement binding; peptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does the function of SERPING1 protein impact the pathophysiology of HAE? 04/18/2023

SERPING1 protein regulates the activity of C1 esterase inhibitor, which in turn modulates the activity of the complement system, leading to the characteristic symptoms of HAE.

What are the implications of genetic mutations in the SERPING1 gene for HAE patients? 12/08/2022

Genetic mutations in the SERPING1 gene can lead to decreased levels or dysfunctional SERPING1 protein, contributing to the development of HAE.

Can the measurement of SERPING1 protein levels be used to monitor treatment response in HAE patients? 04/25/2021

Yes, monitoring SERPING1 protein levels can help assess the effectiveness of HAE treatments and guide adjustments in therapy if needed.

Are there any other clinical conditions associated with aberrations in SERPING1 protein levels? 03/04/2021

Yes, abnormal levels of SERPING1 protein have been implicated in conditions such as preeclampsia, ischemia-reperfusion injury, and sepsis.

How is the role of SERPING1 protein in HAE treatment evolving with advances in biotechnology? 03/28/2019

Biotechnological advances are enabling the development of novel therapeutic modalities targeting SERPING1 protein, such as gene therapies and monoclonal antibodies.

Customer Reviews (3)

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Reviews
04/22/2023

    With their expertise, I can navigate through experimental hurdles, optimize protocols, and ensure the seamless integration of the SERPING1 protein into my investigations.

    05/14/2020

      The SERPING1 protein showcases unparalleled quality, ensuring it surpasses expectations and satisfactorily addresses my experimental requirements.

      12/02/2019

        Their knowledgeable and responsive team stands ready to address any concerns or challenges I may encounter.

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