Human Factor VIII Reference standard

• Cat.No.: F8-38H
• Product Overview: The reference Standard for Blood Coagulation Factor VIII Concentrate, Human, consists of glass ampoules containing 1ml aliquots of human Factor VIII concentrate, freeze-dried. This standard has been calibrated for Factor VIII coagulant activity (FVIII:C) using only the chromogenic method.

Specification

• Species: Human
• Usage: No attempt should be made to weigh out any portion of the freeze-dried material prior to reconstitution. Reconstitute the total contents of each ampoule after warming to room temperature, with 1.0 ml of distilled water, using gentle shaking. Transfer the solution to a plastic tube and keep at room temperature during the assay. Fresh ampoules of standard should be used for each assay.
• Notes: This preparation is not for administration to humans. The preparation contains material of human origin, and either the final product or the source materials, from which it is derived, have been tested and found negative for HBsAg, anti-HIV and HCV RNA. As with all materials of biological origin, this preparation should be regarded as potentially hazardous to health. It should be used and discarded according to your own laboratorys safety procedures. Such safety procedures should include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening ampoules or vials, to avoid cuts.
• Stability: Reference materials are held at Creative Biomart within assured, temperature- controlled storage facilities. Reference Materials should be stored on receipt as indicated on the label. Stability has been assessed in an accelerated degradation study. A predicted degradation rate of 0.21% per year has been obtained for ampoules stored at -20°C. The standard must only be used with the assigned potency and users should not adjust the assigned potency on the basis of this prediction.
• Storage: Store unopened ampoules in the dark at -20°C. Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature.

Gene Information

• Gene Name: F8 coagulation factor VIII, procoagulant component [ Homo sapiens ];
• Official Symbol: F8
• Synonyms: F8; coagulation factor VIII, procoagulant component; F8C; coagulation factor VIII; DXS1253E; Factor VIIIF8B; FVIII; HEMA; hemophilia A; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc; AHF; F8B
• Gene ID: 2157
• mRNA Refseq: NM_000132
• Protein Refseq: NP_000123
• MIM: 300841
• UniProt ID: P00451
• Chromosome Location: Xq28
• Pathway: Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem; Intrinsic Pathway, organism-specific biosystem
• Function: copper ion binding; metal ion binding; oxidoreductase activity; protein binding