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Human Platelet Factor 4(Purified) Reference standard

Cat.No. : PF4-71H
  • Specification
  • Gene Information
  • Related Products
Species : Human
Enzyme Unit : Each ampoule contains 400 International Units.
Usage : No attempt should be made to weigh out any portion of the freeze-dried material prior to reconstitution. The total contents of the ampoule should be reconstituted with 1.0ml distilled water and dissolved by gentle mixing. No attempt should be made to weigh out any portion of the freeze- dried material. The reconstituted standard should be used as soon as possible and unused material should be discarded.
Notes : This preparation is not for administration to humans. The preparation contains material of human origin, and either the final product or the source materials, from which it is derived, have been tested and found negative for HBsAg, anti-HIV and HCV RNA. As with all materials of biological origin, this preparation should be regarded as potentially hazardous to health. It should be used and discarded according to your own laboratorys safety procedures. Such safety procedures should include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening ampoules or vials, to avoid cuts.
Stability : Reference materials are held at Creative Biomart within assured, temperature- controlled storage facilities. Reference Materials should be stored on receipt as indicated on the label. PF4 activity which had been stored at 37 °C, 45 °C, and 56 °C was compared with samples of the same material which had been stored at –20 °C. From the Arrhenius equation relating degradation rate to absolute temperature, the predicted loss of activity at -20 °C is 0.01% per year (upper 95% confidence limit: 0.149% per year).
Storage : Unopened ampoules should be stored in the dark at or below –20°C. Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature.
Gene Name : PF4 platelet factor 4 [ Homo sapiens ];
Official Symbol : PF4
Synonyms : PF4; platelet factor 4; chemokine (C X C motif) ligand 4; CXCL4; SCYB4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; PF-4; MGC138298;
Gene ID : 5196
mRNA Refseq : NM_002619
Protein Refseq : NP_002610
MIM : 173460
UniProt ID : P02776
Chromosome Location : 4q12-q21
Pathway : CXCR3-mediated signaling events, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem;
Function : chemokine activity; heparin binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any therapeutic approaches targeting PF4 protein? 02/17/2023

Some research has explored the development of antibodies targeting PF4 to mitigate its pro-inflammatory effects, although such treatments are still in the early stages of investigation.

How does PF4 protein contribute to the pathogenesis of inflammation? 11/11/2022

PF4 can promote inflammation by recruiting and activating immune cells, such as monocytes and neutrophils, at the site of inflammation.

What are the potential treatment options for patients with HIT? 04/24/2017

Management often involves discontinuing heparin and initiating alternative anticoagulation strategies, such as direct thrombin inhibitors or fondaparinux.

Can PF4 protein be used as a biomarker for other conditions? 06/20/2016

Yes, elevated PF4 levels have been associated with various inflammatory states, making it a potential biomarker for certain diseases.

What diagnostic methods are used to assess PF4 protein levels? 01/30/2016

ELISA (enzyme-linked immunosorbent assay) is commonly used to detect anti-PF4/heparin antibodies in patients suspected of having HIT.

Customer Reviews (3)

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Reviews
09/07/2022

    the PF4 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.

    06/30/2018

      Its impeccable purity and reliability ensure accurate and reproducible results, providing a solid foundation for my research.

      12/12/2017

        he PF4 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.

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