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Antithrombin Reference standard

Cat.No. : F2-180H
Product Overview : The reference Standard for Antithrombin, Plasma, consists of ampoules, containing approximately 1ml aliquots of normal human plasma, freeze dried.
  • Specification
  • Gene Information
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Species : Human
Usage : No attempt should be made to weigh out any portion of the freeze-dried material prior to reconstitution. Allow ampoules to warm to room temperature. Open ampoule, taking care to ensure that all material is in lower part, and reconstitute with 1.0ml distilled water using gentle agitation. Transfer the contents to a plastic tuben store on melting ice and use as soon as possible upon reconstitution.
Notes : This preparation is not for administration to humans. The preparation contains material of human origin, and either the final product or the source materials, from which it is derived, have been tested and found negative for HBsAg, anti-HIV and HCV RNA. As with all materials of biological origin, this preparation should be regarded as potentially hazardous to health. It should be used and discarded according to your own laboratorys safety procedures. Such safety procedures should include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening ampoules or vials, to avoid cuts.
Stability : Reference materials are held at Creative Biomart within assured, temperature- controlled storage facilities. Reference Materials should be stored on receipt as indicated on the label.
Storage : Unopened ampoules should be stored in the dark at or below –20°C. Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature.
Gene Name : F2 coagulation factor II (thrombin) [ Homo sapiens ];
Official Symbol : F2
Synonyms : PT; THPH1; RPRGL2; prothrombin; serine protease; prothrombin B-chain; prepro-coagulation factor II
Gene ID : 2147
mRNA Refseq : NM_000506
Protein Refseq : NP_000497
MIM : 176930
UniProt ID : P00734
Chromosome Location : 11p11
Pathway : Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem
Function : calcium ion binding; growth factor activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you discuss the role of the F2 gene in the synthesis of vitamin K-dependent clotting factors, and how disruptions in this process may lead to coagulation disorders? 04/10/2022

The F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.

How is the F2 gene regulated at the transcriptional level, and what factors influence prothrombin synthesis in hepatocytes? 08/07/2021

Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation. 04/07/2020

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.

What are the implications of genetic variations in the F2 gene, particularly polymorphisms, on prothrombin function and susceptibility to thrombotic or bleeding disorders? 11/20/2019

Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.

How does genetic variation in the F2 gene impact prothrombin levels, and what are the consequences for an individual's risk of thrombotic events? 04/16/2018

Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.

Customer Reviews (3)

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Reviews
01/01/2022

    Quality control is evident. This product ensures accuracy in our studies.

    01/27/2019

      Our lab swears by this protein. Fast shipping is a definite bonus.

      12/18/2018

        Consistently reliable. The shipping speed is appreciated in our fast-paced lab.

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