Recombinant Human Aryl hydrocarbon receptor LBD/Hsp90 complex, GST-tagged

• Cat.No.: AHR-109H
• Product Overview: Recombinant Human GST-tagged Aryl hydrocarbon receptor ligand-binding domain (AhR-LBD) consists of a 218 a.a. GST tag, a 16 a.a. flexible linker and a 207 a.a. Aryl hydrocarbon receptor ligand binding domain, Acc# NP_001612.1, amino acids 231-437. Human Aryl hydrocarbon receptor ligand-binding domain in complex with human Hsp90 was produced in insect cells co-infected with two recombinant baculoviruses. GST tagged AhR-LBD and Hsp90 are the major components of the complex.

Specification

• Description: In the cytoplasm Aryl hydrocarbon receptor is found in complex with Hsp90. Complex of Aryl hydrocarbon receptor with Hsp90 is essential for ligand-dependent activation of the receptor.
• Source: Sf9 insect cells
• Species: Human
• Tag: GST
• Form: 20 mM Na-P pH 8.0, 40 mM KCl, 20 mM Na2MoO4, 7 mM reduced glutathione, 15% glycerol.
• Purity: >80%
• Applications: Development of Ligand binding and coactivator peptide recruitment assays.
• Storage: Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice.
• Publication:
  Hypoxia disrupts aryl hydrocarbon receptor signaling and the Th17 response in allergic rhinitis patients (2018)

Gene Information

• Gene Name: AHR aryl hydrocarbon receptor [ Homo sapiens ]
• Official Symbol: AHR
• Synonyms: AHR; aryl hydrocarbon receptor; bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76
• Gene ID: 196
• mRNA Refseq: NM_001621
• Protein Refseq: NP_001612
• MIM: 600253
• UniProt ID: P35869
• Chromosome Location: 7p15
• Pathway: Adipogenesis, organism-specific biosystem
• Function: DNA binding; DNA binding; Hsp90 protein binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; protein dimerization activity; protein heterodimerization activity; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription factor binding; transcription regulatory region DNA binding