Active Native Human Activated Protein C
Cat.No. : | PROC-64H |
- Specification
- Gene Information
- Related Products
Description : | The Activated Human Protein C was activated from homogeneous protein C by activation with purified alpha-thrombin. The alpha-thrombin is removed after activation. Complete activation is observed on SDS-PAGE. Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography. |
Source : | Human Plasma |
Species : | Human |
Form : | Liquid |
Bio-activity : | Lot dependent |
Molecular Mass : | 56 kDa |
Purity : | Purity by SDS-PAGE: ≥95% |
Usage : | For Research Use Only! Not For Use in Humans. |
Notes : | Centrifuge the vial prior to opening |
Storage Buffer : | In 20 mM Tris-HCl, 0.1 M NaCl, pH 7.4 |
Shipping : | Dry Ice |
Gene Name : | PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Homo sapiens ] |
Official Symbol : | PROC |
Synonyms : | PROC; protein C (inactivator of coagulation factors Va and VIIIa); vitamin K-dependent protein C; autoprothrombin IIA; anticoagulant protein C; blood coagulation factor XIV; PC; APC; PROC1; THPH3; THPH4; |
Gene ID : | 5624 |
mRNA Refseq : | NM_000312 |
Protein Refseq : | NP_000303 |
MIM : | 612283 |
UniProt ID : | P04070 |
Chromosome Location : | 2q13-q14 |
Pathway : | Cell surface interactions at the vascular wall, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Gamma-carboxylation of protein precursors, organism-specific biosystem; |
Function : | calcium ion binding; peptidase activity; protein binding; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
PROC-2432R | Recombinant Rat PROC Protein (42-461 aa), His-tagged | +Inquiry |
PROC-2537H | Recombinant Human PROC protein(51-190 aa), N-SUMO & C-His-tagged | +Inquiry |
Proc-5137M | Recombinant Mouse Proc Protein, Myc/DDK-tagged | +Inquiry |
PROC-1772H | Recombinant Human PROC Protein, His (Fc)-Avi-tagged | +Inquiry |
PROC-3000H | Recombinant Human PROC Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
PROC-272B | Active Native Bovine Activated Protein C | +Inquiry |
PROC-273B | Active Native Bovine Protein C - DEGR (active site blocked) | +Inquiry |
PROC-269B | Active Native Bovine Protein C | +Inquiry |
◆ Lysates | ||
PROC-852HCL | Recombinant Human PROC cell lysate | +Inquiry |
PROC-747MCL | Recombinant Mouse PROC cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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