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Native Bovine Calmodulin

Cat.No. : CALM3-74B
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  • Gene Information
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Description : Calmodulin (CaM) is a ubiquitous, calcium-binding protein that can bind to and regulate a multitude of different protein targets, thereby affecting many different cellular functions. CaM mediates processes such as inflammation, metabolism, apoptosis, muscle contraction, intracellular movement, short-term and long-term memory, nerve growth and the immune response. CaM is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. Many of the proteins that CaM binds are unable to bind calcium themselves, and as such use CaM as a calcium sensor and signal transducer. CaM can also make use of the calcium stores in the endoplasmic reticulum, and the sarcoplasmic reticulum. CaM undergoes a conformational change upon binding to calcium, which enables it to bind to specific proteins for a specific response. CaM can bind up to four calcium ions, and can undergo post-translational modifications, such as phosphorylation, acetylation, methylation and proteolytic cleavage, each of which can potentially modulate its actions.
Source : Bovine Brain
Species : Bovine
Form : Lyophilized
Molecular Mass : 16 kDa
Purity : Purity by SDS-PAGE: ≥95%
Usage : For Research Use Only! Not For Use in Humans.
Notes : Centrifuge the vial prior to opening
Storage : -20°C
Storage Buffer : Lyophilized in 30 mM Hepes, pH 7.4, 1 mM CaCl2 and 0.1 mM DTT.
Reconstitution : In water or aqueous buffer
Shipping : Gel pack
Gene Name : CALM3 calmodulin 3 (phosphorylase kinase, delta) [ Bos taurus ]
Official Symbol : CALM3
Synonyms : calmodulin
Gene ID : 520277
mRNA Refseq : NM_001046249
Protein Refseq : NP_001039714
UniProt ID : P62157
Chromosome Location : chromosome: 18
Pathway : Activation of Ca-permeable Kainate Receptor, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you explain how CALM3 plays a role in the regulation of cardiac muscle contraction? 03/08/2022

CALM3 is essential for regulating calcium levels in cardiac muscle cells. It binds to calcium and activates various proteins that control muscle contraction, ensuring proper heart function.

How does CALM3 interact with other proteins and molecules to modulate cellular functions in a calcium-dependent manner? 11/11/2021

CALM3 interacts with a range of target proteins and enzymes, influencing processes like muscle contraction and cellular responses to calcium.

What are the therapeutic implications of targeting CALM3 in the treatment of conditions like arrhythmias and neurodegenerative diseases? 08/13/2019

Targeting CALM3 may hold therapeutic potential for managing conditions where calcium regulation is disrupted, offering new avenues for treatment and intervention.

How does CALM3 contribute to the modulation of gene expression in response to calcium signaling? 05/26/2018

CALM3 can interact with transcription factors and enzymes to influence gene expression. This is critical for calcium-dependent processes such as muscle development and neural function.

What are the primary functions of CALM3 within cells and biological systems? 01/05/2018

CALM3 is involved in calcium-dependent signaling pathways, regulating processes like muscle contraction, enzyme activation, and gene expression.

Customer Reviews (3)

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02/04/2021

    The product is a reliable partner in my research journey.

    06/08/2020

      This product is a game-changer in terms of laboratory materials.

      12/20/2018

        I've never had any issues with the product; it's a fantastic investment.

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