Active Native Human Fibrinogen (Pg & vWF depleted)
Cat.No. : | FGA-78H |
- Specification
- Gene Information
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Description : | Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolysis fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source. |
Source : | Human Plasma |
Species : | Human |
Form : | Liquid |
Bio-activity : | >95% clottable by functional assays |
Molecular Mass : | 330.00 kDa |
Purity : | Purity by SDS-PAGE: ≥95% |
Usage : | For Research Use Only! Not For Use in Humans. |
Notes : | Centrifuge the vial prior to opening |
Storage : | -80°C |
Storage Buffer : | In 20 mM Sodium Citrate-HCl pH 7.4. |
Shipping : | Dry Ice |
Gene Name : | FGA fibrinogen alpha chain [ Homo sapiens ] |
Official Symbol : | FGA |
Synonyms : | FGA; fibrinogen alpha chain; fibrinogen, A alpha polypeptide; Fib2; MGC119422; MGC119423; MGC119425; |
Gene ID : | 2243 |
mRNA Refseq : | NM_000508 |
Protein Refseq : | NP_000499 |
UniProt ID : | P02671 |
Chromosome Location : | 4q28 |
Pathway : | Amyloids, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Disease, organism-specific biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; |
Function : | eukaryotic cell surface binding; protein binding; protein binding, bridging; receptor binding; |
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◆ Native Protein | ||
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFGA protein levels can be measured through laboratory tests such as fibrinogen assays and coagulation profiles.
FGA protein testing is used as part of the assessment of liver function, as the liver is responsible for the synthesis of fibrinogen.
Low FGA protein levels may lead to an increased risk of bleeding and impaired clot formation.
Conditions such as liver disease, disseminated intravascular coagulation (DIC), and congenital fibrinogen deficiencies can lead to abnormal FGA protein levels.
Treatment for abnormal FGA protein levels may involve addressing the underlying condition and, in some cases, administering fibrinogen replacement therapy.
Customer Reviews (3)
Write a reviewthe manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.
From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the FGA protein in the format and specifications required for their particular studies.
the FGA protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.
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