Native Human Pro-MMP-8
Cat.No. : | MMP8-89H |
- Specification
- Gene Information
- Related Products
Description : | Human neutrophil collagenase (HNC) has been purified from extracts of fresh and outdated buffy coats and from exudates of phorbol myristate acetate-stimulated neutrophils. The MMP-8 present in the starting material can either be latent or active, or have an app. relative molecular mass of 75-kDa and/or 58-kDa. The rather complex pattern of activation of the latent 58-kDa and 75-kDa species by trypsin, organomercurials and oxidants has been investigated. MMP-8 was shown to preferentially hydrolyze type I over type II, and type III collagens in solution and to be a glycoprotein that contains complex N-linked oligosaccharides leading to multiple forms of MMP-8 in SDS-PAGE. The action of endoglycosidase on the latent 58-kDa form produces 42/40-kDa species (Gao et al. 1992, Mallya et al. 1990). This indicates that MMP-8 is an N-linked, complex glycoprotein that appears to be glycosylated at multiple sites |
Source : | Human neutrophil granulocytes (Buffy Coat) |
Species : | Human |
Form : | Liquid |
Molecular Mass : | 40/42 kDa |
Usage : | For Research Use Only! Not For Use in Humans. |
Notes : | Centrifuge the vial prior to opening |
Storage : | -80°C |
Storage Buffer : | In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl?; 1 μM ZnCl?; 0.05% Brij 35; 0,05% NaN? |
Shipping : | Dry Ice |
Gene Name : | MMP8 matrix metallopeptidase 8 (neutrophil collagenase) [ Homo sapiens ] |
Official Symbol : | MMP8 |
Synonyms : | MMP8; matrix metallopeptidase 8 (neutrophil collagenase); CLG1, matrix metalloproteinase 8 (neutrophil collagenase); neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase); HNC; CLG1; MMP |
Gene ID : | 4317 |
mRNA Refseq : | NM_002424 |
Protein Refseq : | NP_002415 |
MIM : | 120355 |
UniProt ID : | P22894 |
Chromosome Location : | 11q21-q22 |
Pathway : | Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; |
Function : | calcium ion binding; metalloendopeptidase activity; peptidase activity; serine-type endopeptidase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
MMP8-5437H | Recombinant Human MMP8 Protein, GST-tagged | +Inquiry |
Mmp8-1127R | Recombinant Rat Mmp8 Protein, His&SUMO-tagged | +Inquiry |
MMP8-3376R | Recombinant Rat MMP8 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP8-4454H | Recombinant Human MMP8 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP8-3719R | Recombinant Rat MMP8 Protein | +Inquiry |
◆ Native Protein | ||
MMP8-1656H | Active Native Human MMP8 Protein | +Inquiry |
◆ Lysates | ||
MMP8-001MCL | Recombinant Mouse MMP8 cell lysate | +Inquiry |
MMP8-2054HCL | Recombinant Human MMP8 cell lysate | +Inquiry |
MMP8-2080MCL | Recombinant Mouse MMP8 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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