Native Human Immunoglobulin E (IgE)

• Cat.No.: IGHE-214H

Specification

• Description: IgE is the least abundant immunoglobulin in plasma, found at a concentration of less that 0.6 micrograms/ml of normal plasma. Elevated IgE levels are found in patients experiencing severe allergic reactions and parasitic infections. In a myeloma condition, IgE is produced by a single clone of plasma cells. The structure of myeloma IgE, however, is normal, and the immunoglobulin purified from a myeloma source is a useful protein for studying immunoglobulin behavior.
• Source: Human Plasma
• Species: Human
• Form: Frozen
• Molecular Mass: MW: 190,000
• Purity: >=95% by SDS-PAGE.
• Usage: For research use only.
• Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Stability: >1 year
• Storage: -20°C
• Storage Buffer: 15 mM potassium phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.

Gene Information

• Gene Name: IGHE Immunoglobulin heavy constant epsilon [ Homo sapiens ]
• Official Symbol: IGHE
• Synonyms: IGHE; Immunoglobulin heavy constant epsilon
• Gene ID: 3497
• Chromosome Location: 14q32.33
• Pathway: FCERI mediated Ca+2 mobilization, organism-specific biosystem; FCERI mediated NF-kB activation, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem
• Function: antigen binding; contributes_to immunoglobulin receptor binding