Native Human Immunoglobulin G3 (IgG3)

• Cat.No.: IGHG3-231H

Specification

• Description: Like IgG1, IgG3 activates complement and has an affinity for fc receptors; thus IgG1 and IgG3 are the more effective of the IgG subclasses. An IgG3 deficiency is associated with Wiscott-Aldrich disease, systemic lupus erythematosus, juvenile diabetes mellitus, and peridontal infections. IgG anti-viral antibodies are restricted to IgG subclasses 1 and 3, with IgG3 antibodies being the first to appear in response to infection.
• Source: Human Plasma
• Species: Human
• Form: Liquid
• Molecular Mass: MW: 170,000
• Purity: >=95% by SDS-PAGE.
• Usage: For research use only.
• Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Stability: >1 year
• Storage: +2 to 6°C; Do NOT Freeze
• Storage Buffer: 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.

Gene Information

• Gene Name: IGHG3 Immunoglobulin heavy constant gamma 3(G3m marker) [ Homo sapiens ]
• Official Symbol: IGHG3
• Synonyms: IGHG3; Immunoglobulin heavy constant gamma 3(G3m marker)
• Gene ID: 3502
• Chromosome Location: 14q32.33
• Pathway: Classical antibody-mediated complement activation, organism-specific biosystem; Complement cascade, organism-specific biosystem; Creation of C4 and C2 activators, organism-specific biosystem
• Function: antigen binding