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Active Native Bovine α-Thrombin

Cat.No. : F2-274B
  • Specification
  • Gene Information
  • Related Products
Description : Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin. During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors factor V and factor VIII. Thrombin has also been reported to activate factor XIII and platelets, and also functions as a vasoconstrictor protein. The procoagulant activity of thrombin is arrested in two ways: 1) inhibition by either heparin cofactor II or the antithrombin III/heparin complex; or 2) complex formation with thrombomodulin. Formation of the thrombin/thrombomodulin complex results in the inability of thrombin to cleave fibrinogen and activate factors V and VIII, but increases the efficiency of thrombin for activation of the anticoagulant, protein C.
Source : Plasma
Species : Bovine
Form : 50% glycerol/water (v/v)
Bio-activity : Fibrinogen clotting or chromogenic assay
Molecular Mass : 36700
Purity : >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin.
Characteristic : Extinction coefficient:19.5, Percent carbohydrate: approximately 5%, Structure: two subunits, approximately Mr=6,000 and 31,000
Storage : -20°C
Gene Name : F2?coagulation factor II (thrombin) [?Bos taurus?(cattle) ]
Official Symbol : F2
Synonyms : prothrombin; thrombin
Gene ID : 280685
mRNA Refseq : NM_173877
Protein Refseq : NP_776302
UniProt ID : P00735
Chromosome Location : chromosome: 15
Pathway : Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem
Function : calcium ion binding; fibrinogen binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you discuss the role of the F2 gene in the synthesis of vitamin K-dependent clotting factors, and how disruptions in this process may lead to coagulation disorders? 04/10/2022

The F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.

How is the F2 gene regulated at the transcriptional level, and what factors influence prothrombin synthesis in hepatocytes? 08/07/2021

Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation. 04/07/2020

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.

What are the implications of genetic variations in the F2 gene, particularly polymorphisms, on prothrombin function and susceptibility to thrombotic or bleeding disorders? 11/20/2019

Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.

How does genetic variation in the F2 gene impact prothrombin levels, and what are the consequences for an individual's risk of thrombotic events? 04/16/2018

Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.

Customer Reviews (3)

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Reviews
01/01/2022

    Quality control is evident. This product ensures accuracy in our studies.

    01/27/2019

      Our lab swears by this protein. Fast shipping is a definite bonus.

      12/18/2018

        Consistently reliable. The shipping speed is appreciated in our fast-paced lab.

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