Active Native Mouse glu-Plasminogen
Cat.No. : | Plg-291M |
- Specification
- Gene Information
- Related Products
Description : | Plasminogen is a single chain glycoprotein zymogen which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.4 μM. The plasminogen molecule contains 790 amino acids, 24 disulfide bridges, no free sulfhydryls and 5 regions of internal sequence homology, known as kringles, between Lys77 and Arg560. These five triple-looped, three disulfide bridged, kringle regions are homologous to the kringle domains in t-PA, u-PA and prothrombin. Plasminogen contains one high affinity (Kd=9x10-6M) and four low affinity (Kd=5x10-3M) lysine binding sites. The high affinity binding site resides within the first kringle region of plasminogen. The interaction of plasminogen with fibrin and α2-antiplasmin is mediated by these lysine binding sites. Native glu-plasminogen (Mr=88,000) is readily converted to Lys-77-plasminogen (Mr=83,000) by plasmin hydrolysis of the Lys76-Lys77 peptide bond. Elastase catalyzed cleavage of the Val441-Val442 peptide bond of glu-plasminogen yields a functionally active zymogen termed Val-442 plasminogen or mini-plasminogen. |
Source : | Plasma |
Species : | Mouse |
Form : | 50% (vol/vol) glycerol/H2O |
Bio-activity : | < 10 ppm plasmin activity for> |
Molecular Mass : | 88000 |
Purity : | >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin. |
Characteristic : | Extinction coefficient:17.0, Isoelectric point:6.2, Structure: single chain, 24 intra chain disulfide bridges, 5 kringle regions. |
Storage : | -20°C |
Gene Name : | Plg plasminogen [ Mus musculus ] |
Official Symbol : | Plg |
Synonyms : | Pg; AI649309; plasminogen; angiostatin; plasmin heavy chain A; plasmin light chain B |
Gene ID : | 18815 |
mRNA Refseq : | NM_008877 |
Protein Refseq : | NP_032903 |
UniProt ID : | P20918 |
Chromosome Location : | 17 A1; 17 8.5 cM |
Pathway : | Activation of Matrix Metalloproteinases, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem |
Function : | apolipoprotein binding; endopeptidase activity; protein domain specific binding |
Products Types
◆ Recombinant Protein | ||
PLG-6846M | Recombinant Mouse PLG Protein, His (Fc)-Avi-tagged | +Inquiry |
PLG-1186P | Recombinant Pig PLG Protein, His-tagged | +Inquiry |
Plg-2673C | Recombinant Chicken Plg Protein, His-tagged | +Inquiry |
PLG-4182R | Recombinant Rat PLG Protein, His (Fc)-Avi-tagged | +Inquiry |
PLG-134H | Recombinant Human PLG Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
PLG -38C | Native Chicken plasmin | +Inquiry |
PLG-30879TH | Native Human PLG | +Inquiry |
PLG -37D | Native Canine plasminogen | +Inquiry |
◆ Lysates | ||
PLG-3109HCL | Recombinant Human PLG 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket