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Active Native Rabbit Lung Thrombomodulin

Cat.No. : THBD-306R
  • Specification
  • Gene Information
  • Related Products
Description : Thrombomodulin (TM) is an integral membrane glycoprotein expressed on the surface of endothelial cells. Its discovery by Esmon and Owen has focused attention on the importance of the protein C anticoagulant pathway. TM serves as a cofactor for protein C activation by forming a 1:1 stoichiometric complex with thrombin (Kd=10-10M), which accelerates the rate of protein C activation by 1000-fold relative to the rate with thrombin alone. In addition to facilitating protein C activation, the binding of thrombin to TM drastically alters the procoagulant activity of thrombin. When bound to TM, thrombin no longer clots fibrinogen, activates factor V, inactivates protein S or triggers platelet aggregation. TM is a single chain protein composed of 5 distinct domains. The domain structure of TM is similar to the low density lipoprotein (LDL) receptor. A short cytoplasmic domain containing a free cysteine is located at the COOH-terminal end and is joined by a membrane spanning region to an O-glycosylation rich domain. The latter is followed by an epidermal growth factor (EGF) homology region and the NH2-terminal hydrophobic domain. The EGF homology region contains 6 EGF-like domains and contains the binding sites for both thrombin and protein C.
Source : Endothelial cell membrane, traces of degraded, yet functional, TM detected in human urine and plasma.
Species : Rabbit
Form : 20 mM Tris, 150 mM NaCl, 0.05% PDOC, pH 7.4
Bio-activity : Protein C activation assay
Molecular Mass : 74000
Purity : >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin.
Characteristic : Extinction coefficient:8.8, Isoelectric point:2.5, Structure:Single chain, NH2-terminal hydrophobic domain, six EGF domains, one O-glycosylation rich domain, one transmembrane domain, COOH-terminal cytoplasmic domain
Storage : -80°C
Gene Name : THBD thrombomodulin [ Oryctolagus cuniculus ]
Official Symbol : THBD
Synonyms : thrombomodulin
Gene ID : 100008887
mRNA Refseq : NM_001082144
Protein Refseq : NP_001075613
Chromosome Location : chromosome: 4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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