Active Native Rabbit Lung Thrombomodulin
Cat.No. : | THBD-306R |
- Specification
- Gene Information
- Related Products
Description : | Thrombomodulin (TM) is an integral membrane glycoprotein expressed on the surface of endothelial cells. Its discovery by Esmon and Owen has focused attention on the importance of the protein C anticoagulant pathway. TM serves as a cofactor for protein C activation by forming a 1:1 stoichiometric complex with thrombin (Kd=10-10M), which accelerates the rate of protein C activation by 1000-fold relative to the rate with thrombin alone. In addition to facilitating protein C activation, the binding of thrombin to TM drastically alters the procoagulant activity of thrombin. When bound to TM, thrombin no longer clots fibrinogen, activates factor V, inactivates protein S or triggers platelet aggregation. TM is a single chain protein composed of 5 distinct domains. The domain structure of TM is similar to the low density lipoprotein (LDL) receptor. A short cytoplasmic domain containing a free cysteine is located at the COOH-terminal end and is joined by a membrane spanning region to an O-glycosylation rich domain. The latter is followed by an epidermal growth factor (EGF) homology region and the NH2-terminal hydrophobic domain. The EGF homology region contains 6 EGF-like domains and contains the binding sites for both thrombin and protein C. |
Source : | Endothelial cell membrane, traces of degraded, yet functional, TM detected in human urine and plasma. |
Species : | Rabbit |
Form : | 20 mM Tris, 150 mM NaCl, 0.05% PDOC, pH 7.4 |
Bio-activity : | Protein C activation assay |
Molecular Mass : | 74000 |
Purity : | >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin. |
Characteristic : | Extinction coefficient:8.8, Isoelectric point:2.5, Structure:Single chain, NH2-terminal hydrophobic domain, six EGF domains, one O-glycosylation rich domain, one transmembrane domain, COOH-terminal cytoplasmic domain |
Storage : | -80°C |
Gene Name : | THBD thrombomodulin [ Oryctolagus cuniculus ] |
Official Symbol : | THBD |
Synonyms : | thrombomodulin |
Gene ID : | 100008887 |
mRNA Refseq : | NM_001082144 |
Protein Refseq : | NP_001075613 |
Chromosome Location : | chromosome: 4 |
Products Types
◆ Recombinant Protein | ||
THBD-4511R | Recombinant Rhesus Macaque THBD Protein, His (Fc)-Avi-tagged | +Inquiry |
THBD-9181M | Recombinant Mouse THBD Protein, His (Fc)-Avi-tagged | +Inquiry |
THBD-138H | Recombinant Human THBD Protein, C-His-tagged | +Inquiry |
Thbd-426R | Recombinant Rat Thbd Protein, His-tagged | +Inquiry |
THBD-0057H | Recombinant Human THBD Protein | +Inquiry |
◆ Lysates | ||
THBD-1220RCL | Recombinant Rat THBD cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All THBD Products
Required fields are marked with *
My Review for All THBD Products
Required fields are marked with *
0
Inquiry Basket