Recombinant Human COL10A1, His-tagged

• Cat.No.: COL10A1-85H
• Product Overview: A DNA sequence encoding human COL10A1 corresponding to amino acid (19-680) was expressed with an N-terminal polyhistidine tag.

Specification

• Description: This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
• Source: Insect cells
• Species: Human
• Tag: His
• Form: Liquid. PBS pH7.4
• AA Sequence: VFYAERYQMPTGIKGPLPNTKTQFF IPYTIKSKGIAVRGEQGTPGPPGPA GPRGHPGPSGPPGKPGYGSPGLQGE PGLPGPPGPSAVGKPGVPGLPGKPG ERGPYGPKGDVGPAGLPGPRGPPGP PGIPGPAGISVPGKPGQQGPTGAPG PRGFPGEKGAPGVPGMNGQKGEMGY GAPGRPGERGLPGPQGPTGPSGPPG VGKRGENGVPGQPGIKGDRGFPGEM GPIGPPGPQGPPGERGPEGIGKPGA AGAPGQPGIPGTKGLPGAPGIAGPP GPPGFGKPGLPGLKGERGPAGLPGG PGAKGEQGPAGLPGKPGLTGPPGNM GPQGPKGIPGSHGLPGPKGETGPAG PAGYPGAKGERGSPGSDGKPGYPGK PGLDGPKGNPGLPGPKGDPGVGGPP GLPGPVGPAGAKGMPGHNGEAGPRG APGIPGTRGPIGPPGIPGFPGSKGD PGSPGPPGPAGIATKGLNGPTGPPG PPGPRGHSGEPGLPGPPGPPGPPGQ AVMPEGFIKAGQRPSLSGTPLVSAN QGVTGMPVSAFTVILSKAYPAIGTP IPFDKILYNRQQHYDPRTGIFTCQI PGIYYFSYHVHVKGTHVWVGLYKNG TPVMYTYDEYTKGYLDQASGSAIID LTENDQVWLQLPNAESNGLYSSEYV HSSFSGFLVAPM
• Purity: >90% as determined by SDS-PAGE
• Storage: Store it at +4°C for short term (5 weeks). For long term storage (12 months), store it at -20? - -70°C. Avoid freeze-thaw cycles.

Gene Information

• Gene Name: COL10A1 collagen, type X, alpha 1 [ Homo sapiens (human) ]
• Official Symbol: COL10A1
• Synonyms: COL10A1; collagen, type X, alpha 1; collagen alpha-1(X) chain; Schmid metaphyseal chondrodysplasia; COAA1_HUMAN; Col10a 1; COL10A1; Collagen alpha 1(X) chain; Collagen alpha-1(X) chain; Collagen type X alpha 1 (Schmid metaphyseal chondrodysplasia); Collagen type X alpha 1; Collagen X alpha 1 polypeptide; CollagenX; fa66d11; fb10c08; OTTHUMP00000040411; Procollagen type X alpha 1; Schmid metaphyseal chondrodysplasia; wu:fa66d11; wu:fb10c08; collagen X, alpha-1 polypeptide
• Gene ID: 1300
• mRNA Refseq: NM_000493
• Protein Refseq: NP_000484
• MIM: 120110
• UniProt ID: Q03692
• Chromosome Location: 6q21-q22
• Pathway: Assembly of c; ollagen fibrils and other multimeric structures; Collagen biosynthesis and modifying enzymes; Endochondral Ossification
• Function: metal ion binding