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Native Porcine UMOD

Cat.No. : UMOD-91P
Product Overview : Porcine Uromodulin is a 97kDa glycoprotein which is produced in the thick ascending limb of Henle´s loop and early distal convoluted tubules of the nephron.
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Description : Uromodulin is the most abundant protein in normal urine. Its secretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin plays a role as a constitutive inhibitor of calcium crystallization in renal fluids. Secretion of uromodulin in urine provides protection against urinary tract infections caused by uropathogenic bacteria. Defects in Uromodulin expression are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. UMOD is involved in regulating the circulating activity of cytokines as it binds to il-1, il-2 and tnf with high affinity.
Source : Porcine Urine
Species : Porcine
Form : Filtered White lyophilized (freeze-dried) powder. The UMOD protein was lyophilized from 0.4µm filtered solution at a concentration of 0.5mg/ml containing deionized water.
Stability : Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Reconstitution : Add deionized water to prepare a working stock solution of approximately 0.5mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does UMOD deficiency or mutation lead to kidney diseases such as tubulointerstitial nephritis? 12/07/2022

Deficiency or mutations in UMOD can lead to kidney disorders like tubulointerstitial nephritis, affecting kidney structure and function.

What role does UMOD play in salt and water reabsorption in the kidney? 08/21/2022

UMOD plays a crucial role in regulating salt and water reabsorption in the kidneys, affecting fluid balance.

How does UMOD (Uromodulin) contribute to normal kidney function and urinary tract health? 04/16/2022

UMOD is key in maintaining kidney and urinary tract health, influencing urine concentration and kidney function.

What is the impact of UMOD on the risk and progression of chronic kidney disease (CKD)? 03/19/2022

UMOD impacts the development and progression of CKD, influencing kidney filtration and health.

How does UMOD influence the immune response in the urinary tract and kidney? 03/28/2021

UMOD contributes to the immune defense in the urinary system, protecting against infections and inflammation.

How do alterations in UMOD expression or function affect blood pressure regulation and cardiovascular health? 11/23/2018

Changes in UMOD function can impact blood pressure and cardiovascular health, due to its role in kidney function and fluid balance.

What are the mechanisms by which UMOD modulates the formation of kidney stones? 11/07/2018

UMOD affects the formation of kidney stones, potentially influencing their development and composition.

Customer Reviews (3)

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Reviews
03/01/2022

    Efficient protein purification, crucial for our research. Highly recommended.

    11/26/2019

      Accurate protein structural analysis, a critical component of our investigations.

      05/30/2019

        Exceptional protein expression optimization support, greatly enhances our research.

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