Native Porcine UMOD
Cat.No. : | UMOD-91P |
Product Overview : | Porcine Uromodulin is a 97kDa glycoprotein which is produced in the thick ascending limb of Henle´s loop and early distal convoluted tubules of the nephron. |
- Specification
- Gene Information
- Related Products
Description : | Uromodulin is the most abundant protein in normal urine. Its secretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin plays a role as a constitutive inhibitor of calcium crystallization in renal fluids. Secretion of uromodulin in urine provides protection against urinary tract infections caused by uropathogenic bacteria. Defects in Uromodulin expression are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. UMOD is involved in regulating the circulating activity of cytokines as it binds to il-1, il-2 and tnf with high affinity. |
Source : | Porcine Urine |
Species : | Porcine |
Form : | Filtered White lyophilized (freeze-dried) powder. The UMOD protein was lyophilized from 0.4µm filtered solution at a concentration of 0.5mg/ml containing deionized water. |
Stability : | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
Reconstitution : | Add deionized water to prepare a working stock solution of approximately 0.5mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
Products Types
◆ Recombinant Protein | ||
UMOD-599D | Recombinant Dog UMOD Protein, His-tagged | +Inquiry |
Umod-602R | Recombinant Rat Umod Protein, His-tagged | +Inquiry |
UMOD-9905M | Recombinant Mouse UMOD Protein, His (Fc)-Avi-tagged | +Inquiry |
UMOD-001H | Recombinant Human UMOD Protein, Myc/DDK-tagged | +Inquiry |
Umod-6833M | Recombinant Mouse Umod Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
UMOD-1885HCL | Recombinant Human UMOD cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionDeficiency or mutations in UMOD can lead to kidney disorders like tubulointerstitial nephritis, affecting kidney structure and function.
UMOD plays a crucial role in regulating salt and water reabsorption in the kidneys, affecting fluid balance.
UMOD is key in maintaining kidney and urinary tract health, influencing urine concentration and kidney function.
UMOD impacts the development and progression of CKD, influencing kidney filtration and health.
UMOD contributes to the immune defense in the urinary system, protecting against infections and inflammation.
Changes in UMOD function can impact blood pressure and cardiovascular health, due to its role in kidney function and fluid balance.
UMOD affects the formation of kidney stones, potentially influencing their development and composition.
Customer Reviews (3)
Write a reviewEfficient protein purification, crucial for our research. Highly recommended.
Accurate protein structural analysis, a critical component of our investigations.
Exceptional protein expression optimization support, greatly enhances our research.
Ask a Question for All UMOD Products
Required fields are marked with *
My Review for All UMOD Products
Required fields are marked with *
Inquiry Basket