Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human TNFRSF18

Cat.No. : TNFRSF18-925H
Product Overview : Recombinant human soluble AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITRL.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Source : E. coli
Species : Human
Form : lyophilized
Bio-activity : Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1.0-10.0 ng/ml. Please Note: Results may vary with PBMC donors.
Molecular Mass : 14.3 kDa
AA Sequence : ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLI YGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE L HVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI
Endotoxin : < 0.1 ng per µg of AITRL
Purity : >97% by SDS-PAGE gel and HPLC analyses.
Usage : Human AITRL offered for research use. Not for drug use. Not for human use.
Stability : The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted Human AITRL should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Reconstitution : The human AITRL should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
Gene Name : TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Homo sapiens (human) ]
Official Symbol : TNFRSF18
Synonyms : Osteostat; TNFSF18; Tumor necrosis factor ligand superfamily member 18; GITRL; TL6; AITRL; hGITRL; MGC138237; AITR ligand; Activation-inducible TNF-related ligand; GITR ligand; Activation-induced TNFR member Ligand; Glucocorticoid-induced TNF-related ligand; Glucocorticoid-induced TNFR-related protein ligand
Gene ID : 8995
mRNA Refseq : NM_005092
Protein Refseq : NP_005083
MIM : 603898
UniProt ID : Q9UNG2
Chromosome Location : 1q23
Pathway : Cytokine-cytokine receptor interaction; Downstream signaling in naive CD8+ T cells
Function : tumor necrosis factor-activated receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
What are some current clinical trials involving TNFRSF18-targeted therapies in cancer treatment? 12/20/2022

Clinical trials are investigating TNFRSF18 agonists, such as monoclonal antibodies, in combination with other cancer treatments in various cancer types.

Are there any approved TNFRSF18-targeted therapies for cancer treatment? 06/29/2019

As of my knowledge cutoff date in January 2022, there were no approved TNFRSF18-targeted therapies for cancer. However, this may have changed since then.

Are there potential side effects associated with TNFRSF18-targeted therapies? 12/30/2018

Side effects may include immune-related adverse events, similar to those seen with other immunotherapies, and can range from mild to severe.

How can TNFRSF18-targeted therapies potentially improve cancer outcomes? 05/05/2018

TNFRSF18-targeted therapies may enhance the body's immune response against cancer cells, leading to better tumor control and improved patient outcomes.

Can TNFRSF18-targeted therapies be used in combination with other immunotherapies? 05/20/2016

Yes, combination therapies involving TNFRSF18 agonists and other immunotherapies are under investigation to improve treatment efficacy.

Customer Reviews (3)

Write a review
Reviews
12/20/2021

    This flexibility enables researchers like myself to tailor TNFRSF18 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.

    03/05/2020

      Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.

      10/01/2017

        The TNFRSF18 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.

        Ask a Question for All TNFRSF18 Products

        Required fields are marked with *

        My Review for All TNFRSF18 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends