Active Recombinant Human TNFRSF18
Cat.No. : | TNFRSF18-925H |
Product Overview : | Recombinant human soluble AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITRL. |
- Specification
- Gene Information
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Description : | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Source : | E. coli |
Species : | Human |
Form : | lyophilized |
Bio-activity : | Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1.0-10.0 ng/ml. Please Note: Results may vary with PBMC donors. |
Molecular Mass : | 14.3 kDa |
AA Sequence : | ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLI YGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE L HVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI |
Endotoxin : | < 0.1 ng per µg of AITRL |
Purity : | >97% by SDS-PAGE gel and HPLC analyses. |
Usage : | Human AITRL offered for research use. Not for drug use. Not for human use. |
Stability : | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted Human AITRL should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles. |
Reconstitution : | The human AITRL should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C. |
Gene Name : | TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Homo sapiens (human) ] |
Official Symbol : | TNFRSF18 |
Synonyms : | Osteostat; TNFSF18; Tumor necrosis factor ligand superfamily member 18; GITRL; TL6; AITRL; hGITRL; MGC138237; AITR ligand; Activation-inducible TNF-related ligand; GITR ligand; Activation-induced TNFR member Ligand; Glucocorticoid-induced TNF-related ligand; Glucocorticoid-induced TNFR-related protein ligand |
Gene ID : | 8995 |
mRNA Refseq : | NM_005092 |
Protein Refseq : | NP_005083 |
MIM : | 603898 |
UniProt ID : | Q9UNG2 |
Chromosome Location : | 1q23 |
Pathway : | Cytokine-cytokine receptor interaction; Downstream signaling in naive CD8+ T cells |
Function : | tumor necrosis factor-activated receptor activity |
Products Types
◆ Recombinant Protein | ||
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Tnfrsf18-2770M | Recombinant Mouse Tnfrsf18 Protein, His-tagged | +Inquiry |
Tnfrsf18-666R | Recombinant Rhesus macaque Tnfrsf18 Protein, Fc-tagged | +Inquiry |
TNFRSF18-154H | Recombinant Human TNFRSF18 Protein, C-His-tagged | +Inquiry |
◆ Lysates | ||
TNFRSF18-1143HCL | Recombinant Human TNFRSF18 cell lysate | +Inquiry |
TNFRSF18-1245RCL | Recombinant Rat TNFRSF18 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionClinical trials are investigating TNFRSF18 agonists, such as monoclonal antibodies, in combination with other cancer treatments in various cancer types.
As of my knowledge cutoff date in January 2022, there were no approved TNFRSF18-targeted therapies for cancer. However, this may have changed since then.
Side effects may include immune-related adverse events, similar to those seen with other immunotherapies, and can range from mild to severe.
TNFRSF18-targeted therapies may enhance the body's immune response against cancer cells, leading to better tumor control and improved patient outcomes.
Yes, combination therapies involving TNFRSF18 agonists and other immunotherapies are under investigation to improve treatment efficacy.
Customer Reviews (3)
Write a reviewThis flexibility enables researchers like myself to tailor TNFRSF18 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.
Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.
The TNFRSF18 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.
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