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Recombinant Chicken ANKH

Cat.No. : ANKH-1934C
Product Overview : Recombinant Chicken ANKH full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Chicken
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : ANKH ANKH inorganic pyrophosphate transport regulator [ Gallus gallus (chicken) ]
Official Symbol : ANKH
Gene ID : 420917
Protein Refseq : NP_001012580
UniProt ID : Q5EEJ9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (11)

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Are there any known diseases associated with mutations in the ANKH gene? 03/07/2023

Yes, mutations in the ANKH gene can lead to several disorders, including familial chondrocalcinosis (a condition characterized by calcium crystal deposition in the joints), familial calcium pyrophosphate deposition disease (CPPD), and craniometaphyseal dysplasia (a condition affecting bone growth and remodelling in the skull and long bones).

Are there ongoing research efforts to develop treatments for ANKH-related diseases? 07/05/2022

Yes, researchers are actively investigating the underlying mechanisms of ANKH-related diseases and exploring potential therapeutic targets. These efforts involve studying the transport mechanisms of inorganic pyrophosphate, exploring genetic therapies, and developing molecules that can modulate the ANKH protein's function. However, more research is needed before targeted therapies become available for these conditions.

What are the potential therapeutic approaches for treating ANKH-related diseases? 09/21/2021

Currently, the treatment options for ANKH-related diseases primarily focus on managing symptoms and slowing down disease progression. For example, nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, and physical therapy can be used to alleviate pain and improve joint function in individuals with anklyosis. In some cases, joint replacement surgery may be necessary.

Are there any animal models or experimental systems used to study the ANKH protein? 08/01/2021

Yes, several animal models have been developed to study the function and role of the ANKH protein. Mice with targeted disruptions in the Ank gene have been generated and utilized to understand the impact of ANKH protein dysfunction. These models have provided valuable insights into the molecular mechanisms underlying ANKH-related diseases and have aided in the development of potential therapeutic interventions. Additionally, in vitro cell culture systems are used to study the ANKH protein's function in specific cell types.

Is there any treatment available for ANKH-related diseases? 11/05/2020

Currently, there is no specific targeted treatment for ANKH-related diseases. Treatment mainly focuses on managing the symptoms and providing pain relief. Nonsteroidal anti-inflammatory drugs (NSAIDs) and other medications to control inflammation and pain are commonly used. In severe cases, joint aspiration or surgical intervention may be required.

Is the ANKH protein expressed in all tissues of the body? 10/05/2020

The ANKH protein is expressed in various tissues throughout the body, including bones, cartilage, kidney, and other soft tissues. It is primarily found in the plasma membrane of cells involved in mineral metabolism. ANKH protein expression is particularly prominent in chondrocytes (cartilage cells) and osteoblasts (cells responsible for bone formation).

Can abnormalities in the ANKH gene lead to other non-skeletal disorders? 12/12/2019

The known disorders associated with ANKH gene mutations primarily affect skeletal tissues such as bones and joints. However, there is some evidence suggesting potential associations between ANKH variants and other conditions, such as atherosclerosis (hardening of arteries) and cardiovascular diseases. These associations are still under investigation, and more research is needed to establish a direct link.

Are there any known environmental factors that can influence ANKH-related diseases? 10/08/2018

While ANKH-related diseases are primarily caused by genetic mutations, environmental factors may play a contributory role in disease development and progression. For example, certain dietary factors, such as high intake of purines or excessive consumption of calcium, have been implicated in the formation of calcium pyrophosphate crystals and the development of chondrocalcinosis. Additionally, mechanical stress on joints and injuries can exacerbate symptoms in individuals with ANKH-related diseases.

How do mutations in the ANKH gene cause these diseases? 02/12/2017

Mutations in the ANKH gene can disrupt the normal function of the ANKH protein, leading to dysregulation of inorganic pyrophosphate transport. This dysregulation can result in abnormal calcium crystal formation and deposition in the joints, leading to conditions like familial chondrocalcinosis and familial CPPD. In the case of craniometaphyseal dysplasia, the mutations can impair bone growth and remodeling processes.

Are there any known genetic variations or polymorphisms in the ANKH gene that are not associated with diseases? 12/04/2016

Yes, there are some genetic variations or polymorphisms in the ANKH gene that have been identified but are not associated with diseases. These variations may have minor effects on the function of the ANKH protein or may not have any significant functional consequences. Some studies have suggested that certain variations in the ANKH gene might be associated with increased susceptibility to certain musculoskeletal disorders, such as osteoarthritis, but more research is needed to confirm these associations.

How common are ANKH gene mutations in the general population? 10/12/2016

ANKH gene mutations are generally rare and are not commonly found in the general population. The prevalence of specific ANKH mutations varies depending on the disorder. For example, certain mutations in the ANKH gene are associated with familial chondrocalcinosis, a condition characterized by the accumulation of calcium pyrophosphate crystals in the joints, and are estimated to occur in less than 1% of the general population.

Customer Reviews (4)

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Reviews
07/23/2021

    the ANKH protein offers significant advantages in trials due to its high quality, purity, and stability.

    04/21/2021

      Their technical expertise and knowledge of the ANKH protein are invaluable resources.

      09/26/2020

        the manufacturer's commitment to continuous innovation and development of new tools and technologies ensures that I have access to the latest advancements in ANKFY1 protein research.

        07/26/2017

          the manufacturer's exceptional support greatly enhances my research process.

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