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Recombinant Human ADAM 10, His-tagged

Cat.No. : ADAM10-265H
Product Overview : RecombinantHuman ADAM 10 comprises a 459 amino acid fragment (214-672) corresponding to the ADAM 10 extracellular domain minus the signal peptide and pro-sequence and is expressed in E. coli with an amino-terminal hexahistidine tag.
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  • Gene Information
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Cat. No. : ADAM10-265H
Description : ADAM 10 is a member of the ADAM family of membrane-anchored cell surface proteins, which contain both a disintegrin and a metalloprotease domain. ADAM 10 is expressed in a wide variety of tissues and resides on both the cell surface and within the cytoplasm. ADAM10 has been implicated in proteolytic release of a number of cell surface proteins in particular TNF alpha.
Source : E.coli.
Purity : >95% by SDS-PAGE
Form : Liquid
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name : ADAM10 ADAM metallopeptidase domain 10 [ Homo sapiens ]
Synonyms : ADAM10; CD156c; HsT18717; MADM; kuz; AD10; KUZ; EC 3.4.24.81; A desintegrin and metalloprotease domain 10; Mammalian disintegrin-metalloprotease; Kuzbanian protein homolog; CDw156c antigen; AD10; CDw156; kuzbanian; CD156c antigen; a disintegrin and metalloprotease domain 10; ADAM metallopeptidase domain 10; ADAM10 ADAM metallopeptidase domain 10.
Gene ID : 102
mRNA Refseq : NM_001110
Protein Refseq : NP_001101
MIM : 602192
UniProt ID : O14672
Chromosome Location : 15q2; 15q22
Pathway : Epithelial cell signaling in Helicobacter pylori infection; Signaling by EGFR; Signaling by Notch
Function : SH3 domain binding; integrin binding; metal ion binding; metalloendopeptidase activity; peptidase activity; protein homodimerization activity; protein kinase binding; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (4)

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What proteins does ADAM10 cleave? 04/25/2022

ADAM10 protein can cleave TNF-α and E-cadherin, etc.

Does adding GST tag have any effect on protein? 07/11/2021

The addition of the GST tag helps protect the recombinant protein from extracellular protease degradation and improves its stability.

How to distinguish between ADAM10 precursors and active bodies? 09/14/2020

The protein size of ADAM10 precursor is larger than that of ADAM10 active.

In addition to cardiovascular tumor-related research, ADAM10 is currently used in the research of which diseases? 08/02/2020

ADAD1 is currently also used in the research of Alzheimer's disease and diabetic retinopathy, etc.

Customer Reviews (3)

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Reviews
09/16/2021

    During the experiment, the technician helped me solve the problems in a timely and accurate manner.

    04/03/2021

      The ADAM10 proteins purchased from your company is suitable for WB.

      09/08/2020

        Received high quality protein products and obtained satisfactory experimental results.

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