Recombinant Human BH3 Interacting Domain Death Agonist

• Cat.No.: BID-380H
• Product Overview: Recombinant BID protein was expressed in E.coli and purified by using conventional chromatography techniques, 21.9 kDa (195 aa).

Specification

• Cat. No.: BID-380H
• Description: BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into the outer mitochondrial membrane. Bax is believed to induce the opening of the mitochondrial voltage-dependent anion channel. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria leading to activation of caspases.
• Sequences of amino acids: MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ NLRTYVRSLA RNGMD
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
• Purity: > 95% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: BID BH3 interacting domain death agonist [ Homo sapiens ]
• Synonyms: BID; BH3 interacting domain death agonist; FP497; MGC15319; MGC42355; BID isoform Si6; BID isoform L(2); BID isoform ES(1b);OTTHUMP00000196197; desmocollin type 4; apoptic death agonist; Human BID coding sequence; BH3-interacting domain death agonist; p22 BID
• Gene ID: 637
• mRNA Refseq: NM_001196
• Protein Refseq: NP_001187
• MIM: 601997
• UniProt ID: P55957
• Chromosome Location: 22q11.1
• Pathway: Apoptosis; Natural killer cell mediated cytotoxicity; Apoptosis
• Function: death receptor binding; protein binding