Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Chicken GNS

Cat.No. : GNS-4389C
Product Overview : Recombinant Chicken GNS full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Chicken
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : GNS glucosamine (N-acetyl)-6-sulfatase [ Gallus gallus (chicken) ]
Official Symbol : GNS
Gene ID : 417829
Protein Refseq : NP_001186488
UniProt ID : F1NI04

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What is the substrate specificity of GNS, and how does it recognize and act on specific sulfated glycosaminoglycans in different tissues? 04/15/2021

GNS exhibits substrate specificity for N-acetylglucosamine-6-sulfate in GAGs. Its recognition of specific sulfated glycosaminoglycans is determined by the structure of the substrate.

Can you elaborate on the catalytic mechanism of GNS and the specific residues involved in substrate binding and catalysis? 03/21/2020

GNS utilizes a catalytic mechanism involving conserved residues. The active site accommodates the substrate, and specific residues play a role in sulfate removal through hydrolysis.

Can you discuss the intracellular trafficking and post-translational modifications of GNS, and their relevance to its enzymatic activity? 10/28/2019

GNS undergoes intracellular trafficking and post-translational modifications essential for its enzymatic activity. Proper folding and trafficking to lysosomes are crucial for functional GNS.

What is the enzymatic role of GNS, and how does it function in the degradation of glycosaminoglycans (GAGs)? 07/02/2019

GNS is a sulfatase enzyme responsible for catalyzing the removal of sulfate groups from N-acetylglucosamine-6-sulfate in glycosaminoglycans, contributing to their degradation.

How does GNS contribute to the maintenance of extracellular matrix integrity, and what are the implications of its dysfunction in diseases like mucopolysaccharidosis type IIID (MPS IIID)? 11/12/2018

GNS is crucial for maintaining extracellular matrix integrity by participating in GAG degradation. Dysfunction of GNS leads to MPS IIID, a lysosomal storage disorder characterized by GAG accumulation.

Customer Reviews (3)

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Reviews
04/21/2022

    Reliability matters in research, and this product consistently delivers. Hats off to their shipping team too!

    02/17/2021

      Prompt shipping and excellent communication. The product has become indispensable in our lab.

      08/29/2019

        Quality is unparalleled. It's evident that they prioritize delivering top-notch products to the labs.

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