Active Recombinant Human TNFSF18

• Cat.No.: TNFSF18-25H
• Product Overview: Recombinant Human TNFSF18(Glu74 - Ser199) was expressed in CHO Cells.

Specification

• Description: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Source: CHO Cells
• Species: Human
• Predicted N Terminal: Tyr
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to induce IL-8 secretion in HT1080 human fibrosarcoma cells transfected with GITR. The ED50 for this effect is typically 4 - 20 ng/mL. The activity can be enhanced approximately 10-fold in the presence of Mouse Anti-Hemagglutinin/HA Peptide Monoclonal Antibody.
• Molecular Mass: Predicted Molecular Mass: 19.6 kDa (monomer)SDS-PAGE: 21-30 kDa, reducing conditions
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: 12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 100 µg/mL in PBS.

Gene Information

• Gene Name: TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Homo sapiens (human) ]
• Official Symbol: TNFRSF18
• Synonyms: Osteostat; TNFSF18; Tumor necrosis factor ligand superfamily member 18; GITRL; TL6; AITRL; hGITRL; MGC138237; AITR ligand; Activation-inducible TNF-related ligand; GITR ligand; Activation-induced TNFR member Ligand; Glucocorticoid-induced TNF-related ligand; Glucocorticoid-induced TNFR-related protein ligand
• Gene ID: 8995
• mRNA Refseq: NM_005092
• Protein Refseq: NP_005083
• MIM: 603898
• UniProt ID: Q9UNG2
• Chromosome Location: 1q23
• Pathway: Cytokine-cytokine receptor interaction; Downstream signaling in naive CD8+ T cells
• Function: tumor necrosis factor-activated receptor activity