Recombinant Human TNFRSF10B(aa 52-212) fused with the Fc portion of human IgG1 was expressed in HEK293, FITC conjugate.
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
Liquid. In PBS containing 0.02% sodium azide.
Inhibits human soluble TRAIL-mediated apoptosis.
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Flow Cytometry: detection of TRAIL cell surface expression.
Stable for at least 6 months after receipt when stored at -20 centigrade.
Long Term Storage: -20 centigrade. Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 centigrade.