"BGLAP" Related Products

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Native Human BGLAP protein

Cat.No.: BGLAP-60H
Product Overview: Native Human BGLAP was purified from Human blood/plasma.
Description: This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.
Source: Human blood/plasma
Species: Human
Form: 20 mM Tris, 150 mM NaCl, pH 7.4
Molecular Mass: 5,800
Purity: >95% by SDS-PAGE
Characteristic: Single chain, one intrachain disulfide bond, Cys 23-29. Three gla residues, 17, 21, 24. Isoelectric Point: 4.0-4.5.
Notes: Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, antiHCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests.
Storage: Store product at or below –80 centigrade.
Concentration: 0.68 mg/ml
Gene Name: BGLAP bone gamma-carboxyglutamate (gla) protein [ Homo sapiens ]
Official Symbol: BGLAP
Synonyms: BGLAP; bone gamma-carboxyglutamate (gla) protein; osteocalcin; bone Gla protein; gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); OC; BGP;
Gene ID: 632
mRNA Refseq: NM_199173
Protein Refseq: NP_954642
MIM: 112260
UniProt ID: P02818
Chromosome Location: 1q25-q31
Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem;
Function: calcium ion binding; hydroxyapatite binding; structural constituent of bone; structural molecule activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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