Recombinant Zebrafish LCK
Cat.No. : | LCK-220Z |
Product Overview : | Recombinant Zebrafish LCK full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | lck LCK proto-oncogene, Src family tyrosine kinase [ Danio rerio (zebrafish) ] |
Official Symbol : | LCK |
Gene ID : | 414333 |
mRNA Refseq : | NM_001001596 |
Protein Refseq : | NP_001001596 |
UniProt ID : | Q6TPQ4 |
Products Types
◆ Recombinant Protein | ||
LCK-174H | Recombinant Human LCK Protein (SH3 Domain), GST tagged | +Inquiry |
LCK-3021R | Recombinant Rat LCK Protein, His (Fc)-Avi-tagged | +Inquiry |
Lck-1300M | Recombinant Mouse Lck Protein, MYC/DDK-tagged | +Inquiry |
LCK-60H | Recombinant Human LCK protein, Flag-tagged, Biotinylated | +Inquiry |
LCK-3524H | Recombinant Human LCK protein, His-tagged | +Inquiry |
◆ Lysates | ||
LCK-681HCL | Recombinant Human LCK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
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Q&As (7)
Ask a questionLCK plays a vital role in the development and maturation of T cells in the thymus, especially during the processes of positive and negative selection, ensuring the generation of a functional and self-tolerant T-cell repertoire.
Yes, LCK activity can be modulated by several pharmacological agents, including kinase inhibitors like dasatinib, which have been explored for therapeutic purposes in various diseases.
LCK activation is regulated post-translationally through phosphorylation at specific tyrosine residues, with its activity being modulated by both activating and inhibitory phosphorylations.
LCK is a pivotal Src family kinase that plays a crucial role in initiating T-cell receptor (TCR) signaling by phosphorylating key tyrosines on the CD3 and ζ-chains of the TCR complex.
LCK interacts with other kinases such as ZAP-70 and Fyn in T-cell signaling pathways, orchestrating a cascade of phosphorylation events that lead to T-cell activation.
Dysregulation of LCK has been associated with various conditions, including autoimmune diseases, immunodeficiencies, and certain leukemias.
LCK contributes to TCR complex formation and activation by phosphorylating the immunoreceptor tyrosine-based activation motifs (ITAMs) on the TCR, facilitating the recruitment and activation of ZAP-70 kinase.
Customer Reviews (3)
Write a reviewGood stability, long shelf-life.
Consistent quality across batches.
Pure product, reliable results.
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