Recombinant Human Glutaredoxin-1

• Cat.No.: GLRX-138H
• Product Overview: Recombinant human Glutaredoxin1 protein was expressed in E.coli and purified by using conventional chromatography techniques, 11.7 kDa (106 aa).

Specification

• Cat. No.: GLRX-138H
• Description: Glutaredoxin(GRX), also known as thioltransferase, is member of the thiol-disulfide oxidoreductase family. Glutraredoxin catalyzes the reversible reduction of protein-glutathionyl mixed disulfides to free sulfhydryl groups though a monothiol mechanism. Mammalian Glutaredoxin is known to have two isoforms, GRX1 and GRX2. GRX1 is a cytosolic protein, whereas GRX2 is localized both in the mitochondria and nucleus. Glutaredoxin-1 may be involved in a various cellular events such as signal transduction, stress response, and metabolic regulation by regulating the redox status of cellular proteins.
• Sequences of amino acids: MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT 10% glycerol
• Purity: > 95% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: GLRX glutaredoxin (thioltransferase) [ Homo sapiens ]
• Synonyms: GRX; GRX1; MGC117407; OTTHUMP00000149979; TTase-1; Thioltransferase-1; glutaredoxin (thioltransferase); GLRX; GLRX1; Glutaredoxin-1;Thioltransferase-1; TTase-1
• Gene ID: 2745
• mRNA Refseq: NM_002064
• Protein Refseq: NP_002055
• MIM: 600443
• UniProt ID: P35754
• Chromosome Location: 5q14
• Pathway: Reactome Event:Nucleotide metabolism
• Function: electron carrier activity; glutathione disulfide oxidoreductase activity; protein N-terminus binding; protein disulfide oxidoreductase activity