Recombinant Human Intercellular Adhesion Molecule-1, His-tagged
Cat.No. : | ICAM1-278H |
Product Overview : | Recombinant Human ICAM-1 comprises a 455 amino acid fragment (28-483) corresponding to the mature extracellular domain of the ICAM protein and is expressed in E. coli with an amino-terminal hexahistidine tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | ICAM1-278H |
Description : | ICAM-1 is a single chain membrane glycoprotein expressed on the surface of a variety of nonhaematopoietic and haematopoietic cell types and has roles in signal transduction, cell signalling and lymphocyte adhesion. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory conditions. |
Source : | E.coli. |
Purity : | >95% by SDS-PAGE |
Applications : | ELISA, Western Blot |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
Gene Name : | ICAM1 intercellular adhesion molecule 1 [ Homo sapiens ] |
Synonyms : | Intercellular adhesion molecule; BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; major group rhinovirus receptor; ICAM1; P3.58; intercellular adhesion molecule 1; ICAM-1; CD54 antigen; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor. |
Gene ID : | 3383 |
mRNA Refseq : | NM_000201 |
Protein Refseq : | NP_000192 |
MIM : | 147840 |
UniProt ID : | P05362 |
Chromosome Location : | 19p13.3-p13.2 |
Pathway : | Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity; Integrin cell surface interactions; Signaling in Immune system |
Function : | integrin binding; protein binding; transmembrane receptor activity |
Products Types
◆ Recombinant Protein | ||
ICAM1-22H | Recombinant Human ICAM1 Protein, Fc-His-tagged | +Inquiry |
ICAM1-2266R | Recombinant Rabbit ICAM1 Protein, His&SUMO-tagged | +Inquiry |
ICAM1-2005R | Recombinant Rhesus Macaque ICAM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ICAM1-14H | Active Recombinant Human ICAM1 Protein (28-480aa), C-hIgG-His-tagged | +Inquiry |
ICAM1-1005R | Recombinant Rhesus ICAM1 Protein (Met1-Glu480), His-tagged | +Inquiry |
◆ Lysates | ||
ICAM1-1970RCL | Recombinant Rat ICAM1 cell lysate | +Inquiry |
ICAM1-2487MCL | Recombinant Mouse ICAM1 cell lysate | +Inquiry |
ICAM1-2655HCL | Recombinant Human ICAM1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, targeting ICAM1 is being explored as a potential therapeutic strategy for inflammatory diseases, with research focusing on developing ICAM1 inhibitors.
ICAM1 is upregulated during inflammation, promoting the adhesion of immune cells to the endothelium and facilitating their migration into inflamed tissues.
ICAM1 expression can be altered in cancer cells and is implicated in promoting cancer progression by facilitating tumor cell adhesion, invasion, and metastasis.
ICAM1 levels can be measured in blood or tissue samples, and elevated levels may serve as diagnostic markers for certain inflammatory diseases.
Elevated levels of ICAM1 in some diseases may serve as prognostic markers, indicating disease severity and potential outcomes.
Customer Reviews (3)
Write a reviewManufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.
This can be particularly important in clinical trials to ensure accurate and reliable results.
If the need arises for larger quantities of ICAM1 protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.
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