Active Recombinant Human PAK4
Cat.No. : | PAK4-18H |
Product Overview : | PAK4KD is a recombinant wild type human PAK4 kinase domain (amino acids 300–591 of full-length human PAK4) expressed in E. coli and purified to homogeneity with full activity. |
- Specification
- Gene Information
- Related Products
Description : | Human PAK4 kinase (UniProt: O96013; NCBI: NM_005884) belongs to a family of p21-activated kinases. These serine/threonine kinases are regulated by the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. |
Source : | E. coli |
Species : | Human |
Form : | 1 mg/ml in Storage Buffer of 25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10% glycerol, 5 mM DTT. |
Bio-activity : | 5,595 pmoles/min/μg |
Molecular Mass : | The calculated mass is 33,309. PAK4KD is fully phosphorylated at S474 with a measured mass of 33,389 (1P). |
AA Sequence : | GPHMSHEQFRAALQLVVDPGDPRSY LDNFIKIGEGSTGIVCIATVRSSGK LVAVKKMDLRKQQRRELLFNEVVIM RDYQHENVVEMYNSYLVGDELWVVM EFLEGGALTDIVTHTRMNEEQIAAV CLAVLQALSVLHAQGVIHRDIKSD SILLTHDGRVKLSDFGFCAQVSKEV PRRKSLVGTPYWMAPELISRLPYGP EVDIWSLGIMVIEMVDGEPPYFNE PPLKAMKMIRDNLPPRLKNLHKVSP SLKGFLDRLLVRDPAQRATAAELLK HPFLAKAGPPASIVPLMRQNRT |
Applications : | Enzymatic studies, inhibitor screen, and selectivity profiling |
Storage : | Stable at -70oC for 12 months from date of receipt. Protein should be thawed on ice. Protein can be flash-frozen in liquid nitrogen and stored at -70oC. |
Gene Name : | PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Homo sapiens ] |
Official Symbol : | PAK4 |
Synonyms : | PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; |
Gene ID : | 10298 |
mRNA Refseq : | NM_001014831 |
Protein Refseq : | NP_001014831 |
MIM : | 605451 |
UniProt ID : | O96013 |
Chromosome Location : | 19p11-q11 |
Pathway : | Activation of Rac, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; |
Function : | ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
PAK4-319H | Recombinant Human PAK4 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Pak4-1894M | Recombinant Mouse Pak4 Protein, His-tagged | +Inquiry |
PAK4-766H | Recombinant Human PAK4 Protein, His-tagged | +Inquiry |
Pak4-4663M | Recombinant Mouse Pak4 Protein, Myc/DDK-tagged | +Inquiry |
PAK4-1603H | Recombinant Human PAK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PAK4-3455HCL | Recombinant Human PAK4 293 Cell Lysate | +Inquiry |
PAK4-3456HCL | Recombinant Human PAK4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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