Recombinant Human Prolactin Receptor, chiMAX Fc Fusion Protein
Cat.No. : | PRLR-76H |
Product Overview : | Prolactin is a neuroendocrine peptide hormone that is secreted primarily by the pituitary gland. Prolactin receptor is a class 1 cytokine transmembrane receptor that varies in size with tissue source and species. It consists of an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region. The extracellular domain (Gln25-Asp234) is expressed recombinantly, purified by chromatography, sterile filtered and lyophilized. >95percent pure by SDS-PAGE and biologically active as measured by inhibitory activity toward prolactin-induced proliferation of Nb2-11 rat lymphoma cells (Gout et al. (1980) Cancer Res. 40:2433). ED50 for this effect is typically< 1.0="" ug/ml="" in="" the="" presence="" of="" 0.5="" ng/ml="" of="" recombinant="" human="" prolactin.="" add="" deionized="" water="" to="" original="" volume,="" aliquot="" and="" freeze="" unused="">This chiMAX Fc Fusion Protein is glycosylated and expressed as a chimera with the Fc region of mouse immunoglobulin (heavy chain hinge, CH2 and CH3). Fc fusion proteins are typically more stable and resistant to degradation and clearance than native cytokines. Fc fusion proteins appear as a dimer in SDS-PAGE under non-reducing conditions. |
- Specification
- Gene Information
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Source : | Insect cell |
Species : | Human |
Form : | Lyophilized powder |
Molecular Mass : | 51,000 |
Purity : | >95% by SDS-PAGE analysis |
Characteristic : | ED50< 1 ug/ml in the presence of 0.5 ng/ml of recombinant human prolactin as determined in a cell proliferation assay using nb2-11 rat lymphoma> |
Usage : | For in vitro laboratory use only |
Notes : | Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet. |
Storage : | -70°C |
Storage Buffer : | PBS |
Shipping : | Cold pack |
Gene Name : | PRLR prolactin receptor [ Homo sapiens ] |
Official Symbol : | PRLR |
Synonyms : | PRLR; prolactin receptor; PRL-R; hPRL receptor; secreted prolactin binding protein; hPRLrI; |
Gene ID : | 5618 |
mRNA Refseq : | NM_000949 |
Protein Refseq : | NP_000940 |
MIM : | 176761 |
UniProt ID : | P16471 |
Chromosome Location : | 5p14-p13 |
Pathway : | Adipogenesis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; ErbB4 signaling events, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; |
Function : | cytokine receptor activity; metal ion binding; ornithine decarboxylase activator activity; peptide hormone binding; prolactin receptor activity; protein homodimerization activity; receptor activity; |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPRLR overexpression or dysregulation has been associated with breast cancer. It can promote cell proliferation and survival through aberrant signaling pathways.
Tissue-specific factors and the presence of co-receptors contribute to the diversity of PRLR signaling outcomes in different tissues and cell types.
The JAK-STAT signaling pathway is a primary pathway activated by PRLR. It involves the activation of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs).
PRLR undergoes endocytosis upon ligand binding, and the internalized receptor-ligand complex is trafficked through intracellular compartments, influencing downstream signaling and receptor recycling.
Phosphorylation is a crucial post-translational modification of PRLR, affecting its activation and downstream signaling. Other modifications, such as glycosylation, also play roles.
Customer Reviews (3)
Write a reviewConsistent quality shines through—this protein has become indispensable.
This protein streamlines our experiments.
Fast shipping made this purchase convenient for our lab operations.
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