Non-enzymatic non-cleavable Recombinant Human tPA
Cat.No. : | PLAT -80H |
Product Overview : | Human tPA with a double mutation that is permanently single chain and lacks catalytic activity. The non-catalytic mutation site is S478A on the mature protein and S513A on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750). The non-cleavable mutation site is R275E on the mature protein and R310E on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750). Recombinantly produced in insect cells. |
- Specification
- Gene Information
- Related Products
Source : | Insect cell |
Species : | Human |
Form : | Frozen liquid |
Molecular Mass : | 70,000 |
Purity : | >95% by SDS-PAGE analysis |
Usage : | For in vitro laboratory use only |
Notes : | Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet. |
Storage : | -70°C |
Concentration : | 2.0 mg/ml |
Storage Buffer : | 0.4M HEPES; 0.1M NaCl; pH 7.4 |
Shipping : | Dry ice |
Gene Name : | PLAT plasminogen activator, tissue [ Homo sapiens ] |
Official Symbol : | PLAT |
Synonyms : | PLAT; plasminogen activator, tissue; tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA); TPA; T-PA; DKFZp686I03148; |
Gene ID : | 5327 |
mRNA Refseq : | NM_000930 |
Protein Refseq : | NP_000921 |
MIM : | 173370 |
UniProt ID : | P00750 |
Chromosome Location : | 8p11.21 |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Dissolution of Fibrin Clot, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Hemostasis, organism-specific biosystem; |
Function : | peptidase activity; protein binding; serine-type endopeptidase activity; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
PLAT-5461H | Recombinant Human Plasminogen Activator, Tissue | +Inquiry |
Plat-4907M | Recombinant Mouse Plat Protein, Myc/DDK-tagged | +Inquiry |
PLAT-72H | Active Recombinant Human PLAT protein(Ile311-Pro562), hFc-tagged | +Inquiry |
Plat-5463M | Recombinant Mouse Plasminogen Activator, Tissue | +Inquiry |
Plat-5462R | Recombinant Rat Plasminogen Activator, Tissue | +Inquiry |
◆ Native Protein | ||
PLAT-30946TH | Native Human PLAT | +Inquiry |
PLAT-29690TH | Native Human Human SERPINE1 | +Inquiry |
PLAT-30920TH | Native Human PLAT | +Inquiry |
◆ Lysates | ||
PLAT-1498MCL | Recombinant Mouse PLAT cell lysate | +Inquiry |
PLAT-2833HCL | Recombinant Human PLAT cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0701 | PLAT (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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