Active Recombinant Human BMPR-1A, His-tagged

• Cat.No.: BMPR1A-28H
• Product Overview: Glycosylated monomer produced in insect cells. The extracellular domain of human BMPR-1A was fused to C-terminal His-tag.

Specification

• Source: Insect cells
• Species: Human
• Tag: His
• Form: Lyophilized. Purity >90% by SDS-PAGE. Endotoxin level:<0.1 ng/μg of>1A.
• Bio-activity: Inhibits rhBMP-2 induced alkaline phosphatase production by C2C12 myogenic cells (ED50=1-3 ng/ml in the presence of 500 ng/ml rhBMP-2).
• Molecular Mass: ~23 kDa.
• Usage: For in vitro research use only. Not for use in diagnostics or in humans.
• Storage: Short term store at -20°C. Long term store at -80°C. Avoid freeze/thaw cycles.
• Reconstitution: We recommend adding sterile PBS containing at least 0.1% HAS or BSA to the vial to prepare a stock solution of no less than 100 μg/ml of BMPR-1A.
• Warning: No warranties, expressed or implied, are made regarding the use of this product. Creative Biomart is not liable for any damage, personal injury, or economic loss caused by this product.

Gene Information

• Gene Name: BMPR1A bone morphogenetic protein receptor, type IA [ Homo sapiens ]
• Official Symbol: BMPR1A
• Synonyms: BMPR1A; bone morphogenetic protein receptor, type IA; ACVRLK3; bone morphogenetic protein receptor type-1A; ALK3; CD292; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-protein kinase receptor R5; SKR5; 10q23del
• Gene ID: 657
• mRNA Refseq: NM_004329
• Protein Refseq: NP_004320
• MIM: 601299
• UniProt ID: P36894
• Chromosome Location: 10q22.3
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Heart Development, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by BMP, organism-specific biosystem; TGF-beta signaling pathway, organism-specific biosystem
• Function: ATP binding; SMAD binding; activin receptor activity, type II; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor activity; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity