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Active Recombinant Human PARP-1

Cat.No. : PARP1-58H
Product Overview : Recombinant protein produced in insect cells (Sf9).
  • Specification
  • Gene Information
  • Related Products
Source : Sf9 cells
Species : Human
Form : 20 μg at 1 mg/mL affinity-purified liquid human recombinant PARP-1 in 100 mM Tris-HCl (pH 7.5) containing 14 mM β-mercaptoethanol, 0.5 mM EDTA, 0.5 mM PMSF and 10% glycerol.
Bio-activity : ~1,018 U/mg protein.
Purity : >99% as determined by SDS-PAGE.
Unit Definition : One unit synthesizes 1 nmole of poly(ADP-ribose) per min. at 25°C, pH 7.5.
Usage : For in vitro research use only. Not for use in diagnostics or in humans.
Storage : Store at -80°C. Aliquot to avoid repeated freeze/thaw cycles.
Warning : No warranties, expressed or implied, are made regarding the use of this product. Creative Biomart is not liable for any damage, personal injury, or economic loss caused by this product.
Gene Name : PARP1 poly (ADP-ribose) polymerase 1 [ Homo sapiens ]
Official Symbol : PARP1
Synonyms : PARP1; poly (ADP-ribose) polymerase 1; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) , ADPRT, poly (ADP ribose) polymerase family, member 1 , PPOL; poly [ADP-ribose] polymerase 1; PARP; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthase 1; poly(ADP-ribosyl)transferase; ADP-ribosyltransferase NAD(+); NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); PPOL; ADPRT; ADPRT1; PARP-1; ADPRT 1; pADPRT-1;
Gene ID : 142
mRNA Refseq : NM_001618
Protein Refseq : NP_001609
MIM : 173870
UniProt ID : P09874
Chromosome Location : 1q41-q42
Pathway : BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Caspase cascade in apoptosis, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem;
Function : DNA binding; NAD binding; NAD+ ADP-ribosyltransferase activity; metal ion binding; protein N-terminus binding; protein binding; transcription factor binding; transferase activity, transferring glycosyl groups; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does PARP1 protein cause cells to die in time? 12/30/2022

Yes, overactivation of the PARP1 protein can lead to apoptosis or necrosis of cells, which may be exploited in the treatment of certain diseases.

How is the PARP1 protein involved in DNA repair? 02/25/2022

The PARP1 protein can repair DNA damage by attaching ADP-ribose groups to damaged DNA strands and recruiting other repair proteins.

What are the other regulatory mechanisms of PARP1 protein in DNA damage repair? 01/07/2022

In addition to PARP1's involvement in direct DNA repair, it can also modulate the selection of repair pathways and initiate other DNA damage sensing mechanisms.

What is the potential of PARP1 protein in tumor immunotherapy? 09/29/2019

Some studies have proposed that the interaction of PARP1 protein with DNA damage in tumor immunotherapy may affect the efficacy of immunotherapy.

Is PARP1 protein involved in cell cycle regulation? 05/19/2019

Yes, the PARP1 protein is involved in the normal regulation of the cell cycle, especially G1/S and G2/M switching during DNA damage.

What are the effects of overactivation of PARP1 protein on cells? 01/07/2019

Overactivation of PARP1 depletes energy stores such as NAD+ and ATP and leads to apoptosis, or cell death.

Customer Reviews (3)

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Reviews
06/01/2020

    This range of applications of PARP1 is breathtaking, and it can play an important role in any field.

    12/02/2019

      This short half-life and high clearance of PARP1 make it have greater potential in the treatment of tumors, infections and other diseases, and it is expected to become a new generation of therapeutic drugs.

      03/18/2019

        The purity and bioactivity of PARP1 make it a valuable resource for scientific research.

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