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Active Recombinant Human MANF, Carrier Free

Cat.No. : MANF-13H
Product Overview : Recombinant human MANF, expressed in Murine myeloma cell line, NS0 derived. Leu22 Leu179 with a C-terminal 6-His tag.
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Description : Mesencephalic astr centigradeyte derived neurotrophic factor (MANF), also known as argininerich, mutated in early stage tumors (ARMET) and argininerich protein (ARP), is a 20 kDa member of the ARMET family of proteins. The name ARMET comes from the fact that the protein was initially thought to be 50 aa longer at the Nterminus and to contain an arginine rich region. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors.
Source : Mammalian cells
Species : Human
Tag : His
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity : Measured by its ability to support the survival and stimulate neurite outgrowth of rat embryonic cortical neurons. The ED50 for this effect is typically 0.7-2.8 μg/mL.
Molecular Mass : 20.4 kDa, reducing conditions.
Endotoxin : <1.0 eu per 1 μg of the protein by the lal</1.0
Purity : >90%, by SDSPAGE under reducing conditions and visualized by silver stain.
Usage : FOR RESEARCH USE ONLY
Quality Control Test : 12 months from date of receipt, 20 to 70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, 20 to 70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 200 μg/mL in sterile PBS.
Warning : Avoid repeated freeze-thaw cycles.
Gene Name : MANF mesencephalic astrocyte-derived neurotrophic factor [ Homo sapiens ]
Official Symbol : MANF
Synonyms : MANF; mesencephalic astrocyte-derived neurotrophic factor; arginine rich, mutated in early stage tumors, ARMET; ARP; arginine-rich, mutated in early stage tumors; ARMET; MGC142148; MGC142150;
Gene ID : 7873
mRNA Refseq : NM_006010
Protein Refseq : NP_006001
MIM : 601916
UniProt ID : P55145
Chromosome Location : 3p21.1
Function : growth factor activity; molecular_function;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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