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Active Recombinant Human Klotho, His-tagged

Cat.No. : KL-388H
Product Overview : Recombinant Human KL(Glu34-Ser981), fused with a C-terminal 6-His tag, was expressed in Mouse NSO Cells.
  • Specification
  • Gene Information
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Description : This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
Source : Mammalian cells
Species : Human
Tag : His
Predicted N Terminal : Glu34
Form : Supplied as a 0.2 µm filtered solution in MES, Glycerol and EDTA.
Bio-activity : Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.025 - 0.1 µg/mL in the presence of 1 µg/mL of rhFGF-23 and 10 µg/mL of Heparin.Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGF RIIIc. The ED50 for this effect is typically 0.025 - 0.1 µg/mL in the presence of rhFGF-23 and Heparin.
Molecular Mass : Predicted Molecular Mass: 109.8 kDaSDS-PAGE: 120-130 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles.12 months from date of receipt, -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after opening.
Gene Name : KL klotho [ Homo sapiens (human) ]
Official Symbol : KL
Synonyms : KL; klotho; NP_004786.2; EC 3.2.1.31
Gene ID : 9365
mRNA Refseq : NM_004795
Protein Refseq : NP_004786
MIM : 604824
UniProt ID : Q9UEF7
Chromosome Location : 13q12
Pathway : Adaptive Immune System; DAP12 interactions; Downstream signaling events of B Cell Receptor (BCR)
Function : beta-glucosidase activity; fibroblast growth factor binding; fibroblast growth factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does KL protein affect cognitive function? 04/08/2022

KL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.

Are there any KL protein-based therapies available for clinical use? 04/07/2022

Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.

Can KL protein supplementation slow down the aging process? 10/25/2021

While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.

How is KL protein measured in clinical settings? 07/19/2018

KL protein levels can be measured in blood and urine samples using various laboratory techniques.

Are there any clinical trials exploring KL protein-based therapies? 04/28/2016

Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.

Customer Reviews (3)

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Reviews
01/31/2021

    The KL protein's reliability and ease of use have made it an essential component of my structural investigations.

    01/22/2019

      Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

      07/22/2016

        Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.

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