Active Recombinant Human Klotho, His-tagged
Cat.No. : | KL-388H |
Product Overview : | Recombinant Human KL(Glu34-Ser981), fused with a C-terminal 6-His tag, was expressed in Mouse NSO Cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. |
Source : | Mammalian cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Glu34 |
Form : | Supplied as a 0.2 µm filtered solution in MES, Glycerol and EDTA. |
Bio-activity : | Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.025 - 0.1 µg/mL in the presence of 1 µg/mL of rhFGF-23 and 10 µg/mL of Heparin.Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGF RIIIc. The ED50 for this effect is typically 0.025 - 0.1 µg/mL in the presence of rhFGF-23 and Heparin. |
Molecular Mass : | Predicted Molecular Mass: 109.8 kDaSDS-PAGE: 120-130 kDa, reducing conditions |
Endotoxin : | < 1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles.12 months from date of receipt, -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after opening. |
Gene Name : | KL klotho [ Homo sapiens (human) ] |
Official Symbol : | KL |
Synonyms : | KL; klotho; NP_004786.2; EC 3.2.1.31 |
Gene ID : | 9365 |
mRNA Refseq : | NM_004795 |
Protein Refseq : | NP_004786 |
MIM : | 604824 |
UniProt ID : | Q9UEF7 |
Chromosome Location : | 13q12 |
Pathway : | Adaptive Immune System; DAP12 interactions; Downstream signaling events of B Cell Receptor (BCR) |
Function : | beta-glucosidase activity; fibroblast growth factor binding; fibroblast growth factor receptor binding |
Products Types
◆ Recombinant Protein | ||
KL-4828M | Recombinant Mouse KL Protein, His (Fc)-Avi-tagged | +Inquiry |
Kl-1714R | Recombinant Rat Kl Protein, His-tagged | +Inquiry |
KL-1071H | Recombinant Human KL Protein, His&SUMO-tagged | +Inquiry |
KL-3220H | Recombinant Human KL Protein, His (Fc)-Avi-tagged | +Inquiry |
KL-2922R | Recombinant Rat KL Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
KL-4936HCL | Recombinant Human KL 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionKL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.
Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.
While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.
KL protein levels can be measured in blood and urine samples using various laboratory techniques.
Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.
Customer Reviews (3)
Write a reviewThe KL protein's reliability and ease of use have made it an essential component of my structural investigations.
Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.
Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.
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