Recombinant Human IL13RA1, His-tagged

• Cat.No.: IL13RA1-48H
• Product Overview: Recombinant human IL13RA1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Description: IL13RA1, also known as Interleukin-13 receptor subunit alpha-1, is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. It is essential for allergen-induced airway hyperactivity and mucus hypersecretion.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid. In Phosphate buffer saline (pH 7.4)
• Molecular Mass: 37.7kDa (328aa) 40-57kDa (SDS-PAGE under reducing conditions.)
• AA Sequence: GGGGAAPTET QPPVTNLSVS VENLCTVIWT WNPPEGASSN CSLWYFSHFG DKQDKKIAPE TRRSIEVPLN ERICLQVGSQ CSTNESEKPS ILVEKCISPP EGDPESAVTE LQCIWHNLSY MKCSWLPGRN TSPDTNYTLY YWHRSLEKIH QCENIFREGQ YFGCSFDLTK VKDSSFEQHS VQIMVKDNAG KIKPSFNIVP LTSRVKPDPP HIKNLSFHND DLYVQWENPQ NFISRCLFYE VEVNNSQTET HNVFYVQEAK CENPEFERNV ENTSCFMVPG VLPDTLNTVR IRVKTNKLCY EDDKLWSNWS QEMSIGKKRN STHHHHHH
• Endotoxin: < 1.0 eu per 1 microgram of protein (determined by lal
• Purity: >90% by SDS - PAGE.
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: IL13RA1 interleukin 13 receptor, alpha 1 [ Homo sapiens ]
• Official Symbol: IL13RA1
• Synonyms: IL13RA1; interleukin 13 receptor, alpha 1; interleukin-13 receptor subunit alpha-1; CD213a1; CD213a1 antigen; IL 13Ra; IL13 receptor alpha 1 chain; NR4; CT19; IL-13RA1; IL-13R-alpha-1; IL-13R subunit alpha-1; cancer/testis antigen 19; IL13 receptor alpha-1 chain; IL-13 receptor subunit alpha-1; bB128O4.2.1 (interleukin 13 receptor, alpha 1); CD213A1; IL-13Ra
• Gene ID: 3597
• mRNA Refseq: NM_001560
• Protein Refseq: NP_001551
• MIM: 300119
• UniProt ID: P78552
• Chromosome Location: Xq24
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL-4 signaling Pathway, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: cytokine receptor activity; protein binding; receptor activity