"NOTCH1" Related Products

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Recombinant Human NOTCH1 protein, Fc-tagged

Cat.No.: NOTCH1-384H
Product Overview: Recombinant Human NOTCH1(Ala19 - Gln526) fused with Fc of Human IgG1 at C-terminal was expressed in NS0.
Source: NS0
Species: Human
Tag: Fc
Predicted N Terminal: Ala19
Form: Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity: Measured by its binding ability in a functional ELISA. Immobilized rhNotch-1 Fc Chimera at 5 µg/mL (100 µL/well) can bind rrJagged-1/Fc Chimera with an apparent KD <5 nM in a functional ELISA.
Molecular Mass: Predicted Molecular Mass: 80.1 (monomer) kDa;SDS-PAGE: 115-125 kDa, reducing conditions.
Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
Gene Name: NOTCH1 notch 1 [ Homo sapiens ]
Official Symbol: NOTCH1
Synonyms: NOTCH1; notch 1; Notch (Drosophila) homolog 1 (translocation associated) , Notch homolog 1, translocation associated (Drosophila) , TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1; hN1; TAN1;
Gene ID: 4851
mRNA Refseq: NM_017617
Protein Refseq: NP_060087
MIM: 190198
UniProt ID: P46531
Chromosome Location: 9q34.3
Pathway: Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem
Function: calcium ion binding; chromatin DNA binding; core promoter binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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