Recombinant Human MSH3 Protein, His-tagged
Cat.No. : | MSH3-494H |
Product Overview : | Recombinant human MSH3 protein with a His-tag was expressed in E. coli |
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Description : | The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | The protein has a calculated MW of 40.3 kDa. |
AA Sequence : | MGSSHHHHHHSSGLVPRGSHMSRRK PASGGLAASSSAPARQAVLSRFFQS TGSLKSTSSSTGAADQVDPGAAAAA AAAAATAPPAPPAPAFPPQLPPHIA TEIDRRKKRPLENDGPVKKKVKKVQ QKEGGSDLGMSGNSEPKKCLRTRNV SKSLEKLKEFCCDSALPQSRVQTES LQERFAVLPKCTDFDDISLLHAKNA VSSEDSKRQINQKDTTLFDLSQFGS SNTSHENLQKTASKSANKRSKSIYT PLELQYIEMKQQHKDAVLCVECGYK YRFFGEDAEIAARELNIYCHLDHNF MTASIPTHRLFVHVRRLVAKGYKVG VVKQTETAALKAIGDNRSSLFSRKL TALYTKSTLIGEDVNPLIKL |
Endotoxin : | <1 EU/μg |
Purity : | >85% by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, Ph7.4, 5% trehalose, 5% mannitol added with 0.25M Arginine |
Gene Name : | MSH3 mutS homolog 3 (E. coli) [ Homo sapiens (human) ] |
Official Symbol : | MSH3 |
Synonyms : | MSH3; mutS homolog 3 (E. coli); mutS (E. coli) homolog 3; DNA mismatch repair protein Msh3; Divergent upstream protein; DUP; Mismatch repair protein 1; MRP1; hMSH3; mismatch repair protein 1; divergent upstream protein; MGC163306; MGC163308; |
Gene ID : | 4437 |
mRNA Refseq : | NM_002439 |
Protein Refseq : | NP_002430 |
MIM : | 600887 |
UniProt ID : | P20585 |
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◆ Recombinant Protein | ||
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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