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Recombinant Human AIM1

Cat.No. : AIM1-561H
Product Overview : Recombinant Human AIM1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Human
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : AIM1 absent in melanoma 1 [ Homo sapiens ]
Official Symbol : AIM1
Gene ID : 202
mRNA Refseq : NM_001624.2
Protein Refseq : NP_001615.1
MIM : 601797
UniProt ID : B3KPT0

Products Types

◆ Recombinant Protein
AIM1-2448H Recombinant Human AIM1 Protein, His (Fc)-Avi-tagged +Inquiry

See All AIM1 Recombinant Protein

Related Gene

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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Are there any drugs or therapies targeting AIM1 protein currently in clinical trials? 10/01/2022

Currently, no drugs or therapies targeting AIM1 protein are in clinical trials. However, preclinical studies have suggested that inhibiting AIM1 protein activity may be a potential therapeutic strategy for cancer treatment.

How is AIM1 protein regulated? 09/25/2022

The regulation of AIM1 protein expression and activity is complex and not fully understood. It has been suggested that various cytokines, growth factors, and extracellular matrix molecules can affect AIM1 protein expression and activity. Additionally, various post-translational modifications have been identified that can modulate its function.

What are the genetic mutations associated with decreased expression of AIM1 protein? 10/15/2021

SNPs and genetic deletions in the AIM1 gene have been associated with decreased expression of AIM1 protein in various cancer types, including melanoma. Additionally, epigenetic modifications (such as DNA methylation) can also regulate AIM1 expression.

Can AIM1 protein be used as a therapeutic target? 10/13/2021

AIM1 protein has been identified as a potential therapeutic target for cancer treatment, particularly in melanoma. Various studies have suggested that targeting AIM1 protein can inhibit cancer cell migration and invasion and promote cancer cell apoptosis.

Are there any therapeutic strategies targeting AIM1 protein? 05/30/2020

Currently, there are no specific therapeutic strategies targeting AIM1 protein. However, studies have shown that overexpression of AIM1 can inhibit tumor growth and induce apoptosis in melanoma cells, suggesting that modulating AIM1 expression may be a potential therapeutic approach. Furthermore, targeting the downstream signaling pathways activated by AIM1 (such as the MAPK/ERK pathway) may also be a therapeutic strategy in cancer treatment.

How is AIM1 protein expression regulated? 05/07/2020

The expression of AIM1 protein is regulated by various factors including genetic mutations, epigenetic modifications, and signaling pathways. For example, studies have shown that the Wnt/β-catenin pathway can upregulate the expression of AIM1 in melanoma cells. Additionally, DNA methylation has been shown to be a key regulator of AIM1 expression, with hypermethylation of the promoter region of the AIM1 gene leading to decreased expression.

Where is AIM1 protein expressed?  03/14/2020

AIM1 protein is expressed in a variety of tissues, including the brain, heart, lung, liver, and skin. Its expression has been found to be upregulated in various types of cancers, including melanoma, breast cancer, and colon cancer.

Is there a link between AIM1 protein and other immune-related diseases? 08/31/2019

Currently, there is no direct link between AIM1 protein and other immune-related diseases. However, there have been suggestions that the downregulation of AIM1 protein expression in cancer cells may contribute to immune system evasion by the tumor.

How is AIM1 protein detected in laboratory tests? 10/23/2018

AIM1 protein can be detected in laboratory tests using methods such as ELISA (enzyme-linked immunosorbent assay) or western blotting. In addition, immunohistochemistry can be used to detect AIM1 protein expression in tissue samples.

Is there a link between AIM1 protein and the immune system? 09/30/2018

There is some evidence indicating that AIM1 protein may be involved in immune system regulation. One study found that AIM1 is expressed in dendritic cells, which are important immune system cells involved in antigen presentation and activation of T cells. This study suggested that AIM1 may play a role in modulating dendritic cell function and regulating T cell responses. Additionally, another study found that AIM1 expression is induced by interferon-gamma, a cytokine involved in immune system activation and inflammation. These findings suggest that AIM1 may have a role in immune system regulation, although further research is needed to fully understand this role.

Is AIM1 protein involved in the regulation of apoptosis? 04/26/2016

There is some evidence suggesting that AIM1 protein may play a role in the regulation of apoptosis. In melanoma cells, overexpression of AIM1 has been shown to induce apoptosis, while knockdown of AIM1 expression has been shown to inhibit apoptosis. The mechanism behind this regulation is not fully understood, but it is thought to be mediated by the activation of the MAPK/ERK signaling pathway.

Can AIM1 protein be used as a biomarker for cancer diagnosis or prognosis? 12/13/2015

Several studies have suggested that AIM1 protein expression could be used as a potential biomarker for cancer diagnosis and prognosis. Decreased expression of AIM1 has been observed in various cancer types, including melanoma, ovarian, lung, and breast cancer, and has been associated with poorer patient outcomes. However, further validation is needed before AIM1 can be used clinically as a biomarker.

Does AIM1 protein interact with other proteins in the cell? 06/11/2015

Yes, AIM1 protein has been shown to interact with various proteins in the cell. One study found that AIM1 interacts with the protein ezrin, which is involved in cell adhesion and cytoskeletal organization, and that this interaction is important for AIM1-mediated suppression of melanoma cell migration. Another study found that AIM1 interacts with the protein Rb1, which is a tumor suppressor gene, and that loss of AIM1 expression results in increased Rb1 phosphorylation and decreased Rb1 activity. There are likely other proteins that interact with AIM1, and further research is needed to fully understand the network of protein-protein interactions involving AIM1.

Customer Reviews (3)

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Reviews
01/15/2023

    This protein acts as a pivotal asset in unraveling the intricate mechanisms associated with ail, expanding the frontiers of knowledge in this particular field.

    09/04/2020

      Their unwavering commitment to customer satisfaction ensures prompt and effective problem-solving, instilling confidence in successfully overcoming any challenges that may arise during my experiments.

      05/11/2017

        Counting on their expertise enables a seamless workflow, optimizing troubleshooting and facilitating comprehensive data analysis.

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