Native Human Kininogen, LMW

• Cat.No.: KNG1-18H
• Product Overview: Native Human Kininogen(LMW) was purified from Human Plasma

Specification

• Description: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
• Source: Human Plasma
• Species: Human
• Form: Lyophilized from 10 mM Na acetate, pH 5.5, with 200 mM NaCl.
• Molecular Mass: 65000
• Purity: >=95% by SDS-PAGE
• Stability: > 1year
• Storage: <= -20o C

Gene Information

• Gene Name: KNG1 kininogen 1 [ Homo sapiens (human) ]
• Official Symbol: KNG1
• Synonyms: KNG1; kininogen 1; BDK; KNG;kininogen-1; HMWK; bradykinin; fitzgerald factor; OTTHUMP00000197128;OTTHUMP00000197129; OTTHUMP00000210109; high molecular weight kininogen;alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor;Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weightkininogen; Williams-Fitzgerald-Flaujeac factor
• Gene ID: 3827
• mRNA Refseq: NM_000893
• Protein Refseq: NP_000884
• MIM: 612358
• UniProt ID: P01042
• Chromosome Location: 3q27
• Pathway: ACEInhibitor Pathway; Class A/1 (Rhodopsin-like receptors); Complement andCoagulation Cascades; Formation of Fibrin Clot (Clotting Cascade); G alpha(i) signalling events; GPCR downstream signaling; GPCR ligand binding
• Function: cysteine-typeendopeptidase inhibitor activity; heparin binding; peptidase inhibitoractivity; receptor binding; zinc ion binding