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Recombinant Human Tyrosine 3-monooxygenase/ Tryptophan 5-monooxygenase Activation Protein, Zeta Polypeptide, His-tagged

Cat.No. : YWHAZ-104H
Product Overview : Recombinant human YWHAZ, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (245 aa, 32kDa).
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Cat. No. : YWHAZ-104H
Description : The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, β, γ, ε, σ, ζ, τ and η that have been identified in mammals. 14-3-3 zeta interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity.
Source : E.coli.
Formulation : Liquid in Phosphate Buffered Saline pH7.4.
Molecular Weight : 32 kDa (245 aa).
Purity : > 95% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequence : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMDK NELVQKAKLA EQAERYDDMA ACMKSVTEQG AELSNEERNL LSVAYKNVVG ARRSSWRVVS SIEQKTEGAE KKQQMAREYR EKIETELRDI CNDVLSLLEK FLIPNASQAE SKVFYLKMKG DYYRYLAEVA AGDDKKGIVD QSQQAYQEAF EISKKEMQPT HPIRLGLALN FSVFYYEILN SPEKACSLAK TAFDEAIAEL DTLSEESYKD STLIMQLLRD NLTLWTSDTQ GDEAEAGEGG EN
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Publication :
14-3-3ζ protein protects against brain ischemia/reperfusion injury and induces BDNF transcription after MCAO in rat (2019)
Gene Name : YWHAZ
Synonyms : YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; KCIP-1; MGC111427; MGC126532; MGC138156; phospholipase A2; 14-3-3 zeta; 14-3-3 protein/cytosolic phospholipase A2; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; OTTHUMP00000165851; OTTHUMP00000165852; OTTHUMP00000165854; OTTHUMP00000165858; OTTHUMP00000165859; OTTHUMP00000165860; YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide.
Gene ID : 7534
mRNA Refseq : NM_001135699.1
Protein Refseq : NP_001129171.1
MIM : 601288
UniProt ID : P63104
Chromosome Location : 8q23.1
Pathway : Cell cycle; Pathogenic Escherichia coli infection - EHEC; Pathogenic Escherichia coli infection - EPEC.
Function : protein domain specific binding; transcription factor binding.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does YWHAZ contribute to cardiovascular diseases? 09/03/2021

YWHAZ is involved in cardiovascular diseases by influencing processes like vascular smooth muscle cell proliferation and apoptosis.

Are there diagnostic applications of YWHAZ in cancer detection? 04/11/2021

Yes, elevated levels of YWHAZ protein have been detected in certain cancers, making it a potential biomarker for cancer diagnosis.

Is YWHAZ a potential biomarker for cardiovascular diseases? 01/27/2018

Preliminary studies suggest that YWHAZ levels may be altered in cardiovascular diseases, making it a candidate biomarker for further investigation.

Can YWHAZ protein be targeted for cancer treatment? 03/27/2016

Research suggests that targeting YWHAZ protein may be a viable strategy for developing anticancer therapies.

Are there potential therapeutic interventions targeting YWHAZ in neurodegenerative disorders? 03/18/2016

Investigational studies are exploring the modulation of YWHAZ as a potential therapeutic approach for neurodegenerative disorders.

Customer Reviews (3)

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10/17/2022

    I greatly appreciate their commitment to ensuring my research is a success.

    01/01/2022

      The YWHAZ Protein offers a wide range of applications, making it highly versatile for various experimental settings.

      11/16/2020

        With the YWHAZ Protein, I have the confidence to generate critical insights and drive significant advancements in my field.

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