Recombinant Human Tyrosine 3-monooxygenase/ Tryptophan 5-monooxygenase Activation Protein, Zeta Polypeptide, His-tagged
Cat.No. : | YWHAZ-104H |
Product Overview : | Recombinant human YWHAZ, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (245 aa, 32kDa). |
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Cat. No. : | YWHAZ-104H |
Description : | The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, β, γ, ε, σ, ζ, τ and η that have been identified in mammals. 14-3-3 zeta interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. |
Source : | E.coli. |
Formulation : | Liquid in Phosphate Buffered Saline pH7.4. |
Molecular Weight : | 32 kDa (245 aa). |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Sequence : | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMDK NELVQKAKLA EQAERYDDMA ACMKSVTEQG AELSNEERNL LSVAYKNVVG ARRSSWRVVS SIEQKTEGAE KKQQMAREYR EKIETELRDI CNDVLSLLEK FLIPNASQAE SKVFYLKMKG DYYRYLAEVA AGDDKKGIVD QSQQAYQEAF EISKKEMQPT HPIRLGLALN FSVFYYEILN SPEKACSLAK TAFDEAIAEL DTLSEESYKD STLIMQLLRD NLTLWTSDTQ GDEAEAGEGG EN |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Publication : |
14-3-3ζ protein protects against brain ischemia/reperfusion injury and induces BDNF transcription after MCAO in rat (2019)
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Gene Name : | YWHAZ |
Synonyms : | YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; KCIP-1; MGC111427; MGC126532; MGC138156; phospholipase A2; 14-3-3 zeta; 14-3-3 protein/cytosolic phospholipase A2; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; OTTHUMP00000165851; OTTHUMP00000165852; OTTHUMP00000165854; OTTHUMP00000165858; OTTHUMP00000165859; OTTHUMP00000165860; YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide. |
Gene ID : | 7534 |
mRNA Refseq : | NM_001135699.1 |
Protein Refseq : | NP_001129171.1 |
MIM : | 601288 |
UniProt ID : | P63104 |
Chromosome Location : | 8q23.1 |
Pathway : | Cell cycle; Pathogenic Escherichia coli infection - EHEC; Pathogenic Escherichia coli infection - EPEC. |
Function : | protein domain specific binding; transcription factor binding. |
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◆ Lysates | ||
YWHAZ-229HCL | Recombinant Human YWHAZ 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYWHAZ is involved in cardiovascular diseases by influencing processes like vascular smooth muscle cell proliferation and apoptosis.
Yes, elevated levels of YWHAZ protein have been detected in certain cancers, making it a potential biomarker for cancer diagnosis.
Preliminary studies suggest that YWHAZ levels may be altered in cardiovascular diseases, making it a candidate biomarker for further investigation.
Research suggests that targeting YWHAZ protein may be a viable strategy for developing anticancer therapies.
Investigational studies are exploring the modulation of YWHAZ as a potential therapeutic approach for neurodegenerative disorders.
Customer Reviews (3)
Write a reviewI greatly appreciate their commitment to ensuring my research is a success.
The YWHAZ Protein offers a wide range of applications, making it highly versatile for various experimental settings.
With the YWHAZ Protein, I have the confidence to generate critical insights and drive significant advancements in my field.
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