Recombinant Human IL2/diphtheria toxin, His-tagged therapeutic protein
| Cat.No. : | diphtheria toxin&IL2-P031H |
| Product Overview : | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. |
- Specification
- Gene Information
- Related Products
| Description : | The expression product is the active ingredient of Ontak. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Molecular Mass : | 57.6 kDa |
| Protein length : | diphtheria toxin fragments A and B (Met 1-Thr 387); IL-2(la 1-Thr 133) |
| AA Sequence : | MGADDVVDSSKSFVMENFSSYHGTK PGYVDSIQKGIQKPKSGTQGNYDDD WKGFYSTDNKYDAAGYSVDNE NPLSGKAGGVVKVTYPGLTKVLALK VDNAETIKKELGLSLTEPLMEQVGT EEFIKRFGDGASRVVLSLPFA EGSSSVEYINNWEQAKALSVELEIN FETRGKRGQDAMYEYMAQACAGNRV RRSVGSSLSCINLDWDVIRDK TKTKIESLKEHGPIKNKMSESPNKT VSEEKAKQYLEEFHQTALEHPELSE LKTVTGTNPVFAGANYAAWAV NVAQVIDSETADNLEKTTAALSILP GIGSVMGIADGAVHHNTEEIVAQSI ALSSLMVAQAIPLVGELVDIG FAAYNFVESIINLFQVVHNSYNRPA YSPGHKTHAPTSSSTKKTQLQLEHL LLDLQMILNGINNYKNP KLTRMLTFKFYMPKKATELKHLQCL EEELKPLEEVLNLAQSKNFHLRPRD LISNINVIVLELKGSETTFMC EYADETATIVEFLNRWITFCQSIIS TLT |
| Endotoxin : | < 1.0 EU per μg of the protein |
| Purity : | >95% |
| Storage : | Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles. |
| Gene Name : | IL2 interleukin 2 [ Homo sapiens ] |
| Official Symbol : | IL2 |
| Synonyms : | IL2; interleukin 2; interleukin-2; IL 2; T cell growth factor; TCGF; aldesleukin; involved in regulation of T-cell clonal expansion; IL-2; lymphokine; |
| Gene ID : | 3558 |
| mRNA Refseq : | NM_000586 |
| Protein Refseq : | NP_000577 |
| MIM : | 147680 |
| UniProt ID : | P60568 |
| Chromosome Location : | 4q26-q27 |
| Pathway : | Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; |
| Function : | carbohydrate binding; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding; kinase activator activity; |
Products Types
| ◆ Recombinant Protein | ||
| IL2-159R | Active Recombinant Rat IL2 Protein | +Inquiry |
| IL2-30H | Active Recombinant Human IL2 Protein, Animal Free | +Inquiry |
| IL2-171P | Recombinant Active Pig IL2 Protein, His-tagged(C-ter) | +Inquiry |
| IL2-2693R | Recombinant Rat IL2 Protein, His (Fc)-Avi-tagged | +Inquiry |
| IL2-03C | Recombinant Chicken IL2 Protein, Biotinylated Conjugated | +Inquiry |
| ◆ Lysates | ||
| IL2-5234HCL | Recombinant Human IL2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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