Active Recombinant Human TDO2, MYC/DDK-tagged

• Cat.No.: TDO2-824H
• Product Overview: Recombinant Human TDO2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Bio-activity: The specific activity of TDO2 was determined by monitoring Kynurenine formation from the N-formylkynurenine based on the absorbance at 492nm.
• Molecular Mass: 47.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TDO2 tryptophan 2,3-dioxygenase [ Homo sapiens (human) ]
• Official Symbol: TDO2
• Synonyms: TDO; TPH2; TRPO; TDO2; tryptophan 2,3-dioxygenase; TO; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase; EC 1.13.11.11
• Gene ID: 6999
• mRNA Refseq: NM_005651
• Protein Refseq: NP_005642
• MIM: 191070
• UniProt ID: P48775
• Chromosome Location: 4q31-q32
• Pathway: Metabolic pathways; Tryptophan metabolism; Metabolism of amino acids and derivatives
• Function: amino acid binding; heme binding; metal ion binding; oxidoreductase activity; oxygen binding; oxygen binding; tryptopha 2,3-dioxygenase activity