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Recombinant Marmoset TFRC Protein, His-tagged

Cat.No. : Tfrc-01M
Product Overview : Recombinant Marmoset TFRC Protein With His tag was expressed in HEK293.
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Description : Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
Source : HEK293
Species : Marmoset
Tag : His
Molecular Mass : 76.5 kDa
AA Sequence : GYCKHVEPKIECQRLAGTESPAVEN PEENLPVVPQLYWDDLKKMLSEKLD TTDFTSTIKLLNENSYVPREAGSQK DENLAWYIENQFRECKLSKVWRDEH FVKIQVKDSAQNSVTITGTNSEFVY LVENPGGYVAYSQNATVTGKLVHAN FGTEKDFEDLDSPVNGSIVIVRAGK ITFAEKVANAESANAIGVLIYMDKT KFPIVDADVSFFGHAHLGTGDPYTP GFPSFNHTQFPPSRSSGLPNIPVQT ISRAAAERLFENMEGDCPSDWKTDS SCRMVTSQNKSVKLSVSNVMKEIKI LNIFGVIKGFVEPDRYVVVGAQRDS WGPGAAKSSVGTALLLELAQTFSDM VLKDGFQPSRSIVFASWSAGDFGSV GATEWLEGYLSSLHLKAFTFINLDK AVLGTSNFRVSASPLLYALIEKTMQ EVKHPVTGLSLYQDSNWASKVEKLT FDNAAFPFLAYSGIPAVSFCFCEDT DYPYLGTTMDTYKELIEKIPQLNKV ARAAAEVAGQFMIKLTHDVELNLDY ERYNSQLLSFLRNLNQYRADIREMG LSLQWLYSARGDFFRATSRLTTDFK NSEKTDRFVMKELNDRVMKVEYYFL SPYVSPRESPFRHIFWGSGSHTLSA LLEHLKLRKTNNRAFNETLFRNQLA LATWTIQGAANALSGDIWDIDNEFH HHHHH
Purity : > 90% by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 1.54 mg/mL
Storage Buffer : PBS, pH 7.4
Gene Name : TFRC transferrin receptor [ Callithrix jacchus (white-tufted-ear marmoset) ]
Official Symbol : TFRC
Synonyms : TFRC; transferrin receptor; transferrin receptor protein 1; transferrin receptor (p90, CD71); transferrin receptor 1
Gene ID : 100407510
mRNA Refseq : NM_001301847
Protein Refseq : NP_001288776
UniProt ID : H9BFK5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can TFRC be used to develop targeted drug delivery systems? 09/13/2022

Yes, TFRC's presence on cell surfaces has been exploited for the development of targeted drug delivery systems, especially for delivering drugs to cancer cells.

Are there any therapies that target TFRC in cancer treatment? 11/17/2020

Yes, some experimental therapies aim to target TFRC on cancer cells, such as antibody-drug conjugates (ADCs) and small-molecule inhibitors.

Are there any clinical conditions associated with TFRC protein dysregulation? 09/19/2017

Yes, dysregulation of TFRC expression or function can be associated with various medical conditions, including anemia, cancer, and neurodegenerative diseases.

How is TFRC protein studied in clinical research and diagnostics? 10/03/2016

Researchers use techniques like immunohistochemistry and molecular assays to study TFRC expression levels in patient samples. This helps in diagnosis and prognosis.

How can TFRC be relevant in the treatment of iron-deficiency anemia? 01/02/2016

Understanding TFRC expression in the context of anemia can help identify the underlying causes and guide treatment strategies to improve iron uptake.

Customer Reviews (3)

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Reviews
09/06/2021

    In addition to the advantages of GAD1 protein itself, the manufacturer can play a crucial role in supporting the research efforts.

    04/19/2018

      This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.

      01/27/2017

        This versatility enables researchers to explore GAD1's function and role in a range of biological processes, making it a valuable tool across diverse research fields.

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